As 3D printing is increasingly used in many areas, medical science is not left behind. From standard applications such as medical device and prosthesis printing to more advanced applications such as cartilage and bone printing, the success of 3D printing technologies in the medical field is growing rapidly.
One of the last breakthroughs is the world's first 3D vascularization process manufactured heart with the patient's own cells and biological material. So far, scientists could only print simple tissues without blood vessels. Tel Aviv University researchers used patients' adipose tissue to separate the cellular and acellular materials and programmed the cells into pluripotent stem cells. The extracellular matrix (ECM) was processed into a personalized hydrogel that served as the basis for the print.
This heart is made from human cells and patient-specific biological materials. In our process, these materials serve as bio-compounds, substances from sugars and proteins that can be used for the 3D printing of complex tissue models. At this stage, our 3D heart is small, as big as a rabbit heart, but larger human hearts require the same technology.
After mixing with the hydrogel, the cells were efficiently differentiated into cardiac or endothelial cells to create patient-specific, immunocompatible blood vessel heart plasters and then whole heart that fully matches the immune system, cellular, biochemical and anatomical characteristics of the patient. The difficulty of printing fully-formed organs has long been addressed, and we have talked about it in the past.
The development of this technology can completely solve both the problem of organ compatibility and organ rejection.