The crash happened off Roatan island, a tourist destination on the Atlantic coast of Honduras.
The Piper PA-32-260 is planning to head to the tourist port city of Trujillo, about 49 miles from Roatan, an island frequented by tourists from the United States, Canada and Europe, authorities told Reuters.
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A State Department spokesperson confirmed to Fox. Embassy in Tegucigalpa is "providing all appropriate consular assistance."
"We express our condolences to all affected by this tragedy," a spokesperson said.
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Global Affairs Canada told CTV News that a Canadian citizen what happened among those killed in the crash.
"Citizen who died in a tragic plane crash in Roatan Islands, Honduras. Canadian consular officials in Tegucigalpa, Honduras are in contact with local authorities and are looking to the family of the victims, "a Global Affairs Canada spokesperson told CTV.
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Officials said that firefighters responded quickly to the crash site, where four of the passengers were dead.
Honduras local authorities did not immediately offer a cause for the accident, Reuters reported.