Hospitalization COVID-19 Patients with adequate vitamin D and 25-hydroxyvitamin D blood levels of at least 30 ng / ml (a measure of vitamin D status) had a significantly reduced risk of adverse clinical outcomes, including unconsciousness, hypoxia (starved body) and oxygen Death. They also had lower levels of a marker of inflammation (C-reactive protein) in the blood and higher levels of lymphocytes (a type of immune cell used to fight infections).
“This study provides direct evidence that adequate levels of vitamin D can reduce complications, including the cytokine storm (too many proteins released in the blood too quickly) and ultimately death from COVID-19,” explained author Michael F. Holick, PhD. MD, Professor of Medicine, Physiology and Biophysics, and Molecular Medicine at Boston University School of Medicine.
A blood sample to measure vitamin D status (measured serum level of 25-hydroxyvitamin D) was taken from 235 patients admitted to hospital with COVID-19. These patients were evaluated for clinical outcomes including clinical severity of infection, loss of consciousness, difficulty breathing leading to hypoxia, and death. The blood was also analyzed for a marker of inflammation (C-reactive protein) and for the number of lymphocytes. The researchers then compared all of these parameters in patients with vitamin D deficiency with those in whom vitamin D was sufficient.
In patients older than 40 years of age, they observed that those with enough vitamin D were 51.5 percent less likely to die from the infection than those with vitamin D deficiency or insufficient vitamin D with one Blood levels of 25-hydroxyvitamin D less than 30 ng / ml.
Holick, who recently published a study that found that getting enough vitamin D could reduce your risk of contracting coronavirus by 54 percent, believes that getting enough vitamin D helps Fighting the consequences of infection not only with the coronavirus but also with other viruses causing diseases of the upper respiratory tract including influenza. “There is great concern that the combination of influenza infection and coronal viral infection could significantly increase hospital admissions and death from complications from these viral infections.”
According to Holick, this study offers a simple and inexpensive strategy to improve the ability to fight the coronavirus and reduce the adverse clinical outcomes of COVID-19, including the need for ventilatory assistance, an overactive immune response that leads to cytokine storm and death. “Because vitamin D deficiency and insufficiency are so common in children and adults in the US and around the world, especially during the winter months, it is advisable for everyone to take a vitamin D supplement to reduce the risk of infection and reduce complications from COVID. 19. ”
Reference: “Vitamin D deficiency, a serum 25-hydroxyvitamin D at least 30 ng / ml reduced risk of adverse clinical outcomes in patients with COVID-19 infection” by Zhila Maghbooli, Mohammad Ali Sahraian, Mehdi Ebrahimi, Marzieh Pazoki, Samira Kafan , Hedieh Moradi Tabriz, Azar Hadadi, Mahnaz Montazeri, Mehrad Nasiri, Arash Shirvani and Michael F. Holick, 25 September 25 2020, PLUS ONE.
DOI: 10.1371 / journal.pone.0239799