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Advances in Identification, Prevention of Brain Diseases



Scientists are about to reach a long-awaited goal – a blood test to identify possible signs of Alzheimer's and other brain diseases Such conditions, even if they have genes that increase this risk.

At the International Conference of the Alzheimer's Association on July 15, six research groups presented new results on several experimental tests. This included one that seems to [889] exactly to identify Alzheimer's risk.

Doctors hope that in regular examinations, they can use something that can measure most signs of brain-destroying disease. You could better decide which patients need additional testing. Current instruments such as brain scans (1

9459004) and spinal tests (19459005) are too costly or difficult to meet regularly with patients.

"We need something faster … It does not have to be perfect," said Maria Carrillo, scientific director of the Alzheimer's Society.

Richard Hodes is director of the National Institute for Aging Research. He called the new results "very promising". He said that blood screening for selection and observation of individuals will soon be used for studies supported by the federal government.

"This has happened … much faster than any of us would have expected," he told The Associated Press.

It can not be too early for patients like 66-year-old Tom Doyle. The former university professor from Chicago first had memory problems four years ago. Since then he has performed two spinal fluid tests.

He was first told that he did not have Alzheimer's disease. Later he was told that he had it. Over time, doctors found that Doyle suffered from various dementia-related illnesses – Lewy body and Parkinson's.

"You probably could have diagnosed me years ago if you had a blood test," Doyle said. He represents patients in the leadership team of the Alzheimer's Association.

  In this photo from July 9, 2019, Dr. Jori Fleisher, neurologist, Thomas Doyle, 66, at Rush University Medical Center in Chicago. 66-year-old Doyle hopes that one day blood tests will replace invasive diagnostic tests that he diagnosed for 4.5 years.

In this photo from July 9, 2019, the neurologist Dr. med. Jori Fleisher, the 66-year-old Thomas Doyle at the Rush University Medical Center in Chicago. 66-year-old Doyle hopes that one day blood tests will replace the invasive diagnostic tests that he endured for 4.5 years.

About 50 million people worldwide suffer from dementia. Alzheimer's is the most common type. There is no cure. Current medicines only temporarily relieve their harmful effects. Many hoped treatments have failed. Doctors believe that previous studies included people who were too late in the disease when the brain damage was already severe. The experts also say that the research may have involved too many people with problems other than Alzheimer's.

A blood test – and no subjective assessment of thinking ability – could involve the right people in the right studies earlier.

One of the experimental blood tests measures unusual types of protein that forms plaque in the brain. Plaque is an important sign of Alzheimer's. Last year, Japanese researchers published a study about it. At the conference, they released results of additional tests on 201 people with Alzheimer's or other dementias.

Akinori Nakamura is at the National Center for Geriatrics and Gerontology in Obu, Japan. He said that the test properly identified 92 percent of people with and 85 percent without Alzheimer's.

Another experimental test is Neurofilament Light, a protein that is a marker of nerve damage. Abdul Hye of King's College London announced results from a study comparing blood levels of 2,300 people with various brain disorders, including dementia, depression, Parkinson's disease and multiple sclerosis. For comparison, healthy individuals were also included in the study.

Eight of the diseases were associated with much higher neurofilament light levels. The test can not show what disorder someone might have. But it can help you to eliminate disturbances in a patient.

Randall Bateman of the Washington University Medical School in St. Louis also helped develop a blood test that measures the Alzheimer's protein. His work is supported by the United States Government and the Alzheimer's Association.

"Everyone finds the same … the results are remarkably similar in different countries and techniques," said Bateman. He estimates that a test could be completed in three years.

Recent advances in dealing with conditions such as Alzheimer's were not limited to treatment.

Researchers at the conference also presented a new study to prevent these diseases. The study also appeared in the scientific publication of the Journal of the American Medical Association.

It turned out that people with high genetic risk and poor health are about three times more likely to suffer from dementia than people with low dementia genetic risk and good habits. And at every genetic risk, good nutrition, regular exercise, limited alcohol intake, and no tobacco use have reduced the likelihood of dementia.

  This Thursday, September 27, 2018, an elderly couple will pass the Berlaymont headquarters of the European Commission in Brussels. Research published on Sunday, July 14, 2019, suggests that a healthy lifestyle can reduce the risk of development.

This Thursday, September 27, 2018, an elderly couple will walk past the Berlaymont building, the seat of the European Commission, past Brussels. Studies published on Sunday, July 14, 2019, suggest that a healthy lifestyle can reduce the risk of development without signs of dementia. The subjects were classified as having high, moderate or low risk of dementia due to genetic mutations . The subjects were also grouped by lifestyle factors .

After about eight years of observation, 1.8 percent of people at high genetic risk and unhealthy behavior developed dementia. Just over half a percent of people with low genetic risk and healthy habits had the disease.

John Haaga of the National Institute on Aging says the study results are good news.

I'm going to escape this … disease, "but clean living can improve your chances, Haaga said.

A limitation of the study is that researchers only had information about mutations affecting people of European descent.

The findings should alleviate gene mutation fears Alone brain health matters, said Rudy Tanzi, a geneticist at Massachusetts General Hospital. Less than 5 percent of Alzheimer's mutations are "completely pervasive," meaning they guarantee that a person gets the disease.

"That means 95 percent of the mutations make your lifestyle a difference," Tanzi said. "Do not worry about your genetics, spend more time looking after a healthy life."

I'm Dorothy Gundy.

And I'm Pete Musto.

Pete Musto adapted this story for VOA Learning English using Associated Press materials. Caty Weaver was the publisher. We want to hear from you. What further progress do you hope to achieve in the fight against the brain and other diseases? Write us in the comments or on our Facebook page.

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Words in this story

Exactly Adj. Free from errors or errors

Regular Adv , happens at times that are equally separated from each other

scan ( s ) – n. the plot or act, using a special machine to see the inside of something like a body part

spine adj. of, with respect to or to diagnose the line of connected bones in the middle of the back

d ) – v. to recognize a disease or illness in someone

Subjectively adj. based on feelings or opinions rather than facts

Plaque n. A change in brain tissue that occurs in Alzheimer's Disease

Habitus ( s ) – n. a common mode of behavior

mutation ( s ) – n. a change in the genes of a plant or animal that produces other physical properties than what is normal

factor ( s ) – n. something that helps to produce or influence an outcome


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