UAB scientists generated genetic optimization in mice to cause skin wrinkles and hair loss and reverse them, a finding that could possibly used to develop treatments for these conditions in humans.
Wrinkles and baldness are some of the most visible signs of aging. For the study, the researchers induced a mutation in mice that caused them to lose coat and develop wrinkles. The gene caused mitochondrial dysfunction in rodents, according to a UAB press release.
The affected mice developed wrinkled skin and pronounced hair loss within weeks. When the researchers reversed the mutation and discontinued mitochondrial dysfunction, many of the wrinkles disappeared and the fur returned.
Keshav Singh, senior scientist at UAB's Comprehensive Cancer Center, led the study.
"This mouse model should provide an unprecedented opportunity to develop preventive and therapeutic drug development strategies to increase mitochondrial function in the treatment of aging-associated skin and hair pathology and other human diseases in which mitochondrial dysfunction plays a significant role," Singh said in a paper Press release. [1
Study results were recently published in the online journal Cell Death and Disease