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Alzheimer's disease related to gum disease, new study finds



In recent years, we suspect that Alzheimer's is more than just a degenerative disease of the brain. Instead, the researchers believe it could be infection-related. This is a big deal because there is currently no cure for Alzheimer's and no new dementia treatments have been developed in the last 15 years. Alzheimer's disease is the fastest growing epidemic in America.

A new study published in the journal Science Advances has now brought an interesting (and unexpected) breakthrough. It has been shown that the bacterium Porphyromonas gingivalis – that is the causative agent known for the development of a chronic gum disease ̵

1; – is found in the brain of Alzheimer's patients. Gum disease, also known as periodontitis, is caused by the accumulation of bacteria between the gums and teeth, which can cause the tooth to become inflamed. Risk factors for gum disease are age, smoking, diet and even genetics.

How exactly is this relationship relevant? The results of the study showed that even toxic proteases produced by the bacterium are found in the brain and that the levels of these proteases (gingipain) correlate with the tau pathology and other prominent signs of Alzheimer's disease. This means that targeting gingipains or gum disease could primarily help prevent or treat Alzheimer's disease in the future.

The researchers around Jan Potempa, a microbiologist at the University of Louisville, went one step further. They infected mice with Porphyromonas gingivalis and found that this led to colonization of the bacteria in the brain and to an increase in amyloid beta (Aβ), another important marker of Alzheimer's disease, but now it does is a step in the right direction, and this is an interesting advance in trying to figure out how to target Alzheimer's prevention and treatment. What can you do now to avoid problems with your brain health in the future? Alzheimer's is often referred to as Type 3 diabetes because it is closely related to lifestyle factors such as your level of activity and sugar-rich sugar. Begin to move freely and reduce the intake of processed and refined foods. Then make sure you get regular dental check-ups and brushing and flossing to prevent gingivitis.


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