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An 'EpiPen' for spinal cord injuries could prevent paralysis



When your body suffers from trauma, its fierce army of immune cells go to work – clearing out dead and damaged tissue as well as beefing up the injured area's defense against infection. But for the some 12,000 new cases of spinal cord injury in the US annually, the body's immune system can often do more harm than good, causing nerve damage, numbness, even paralysis.

In this work, we demonstrate that instead of: "In this work, we demonstrate that instead of" "Overcoming an immune response, we can co-opt the immune response to work to promote the therapeutic response," says Lonnie Shea, a biomedical engineering professor at UM, whose research has been published in the Proceedings of the National Academy of Sciences. [1

9659002] The central nervous system, which includes the spinal cord, is usually protected from our aggressive immune activity thanks to the blood-brain barrier – a complex of endothelial cells that help block toxins, patho

However, spinal trauma often leads to a break in this barrier, causing rapid death of neurons,

Physicians used to use steroids as well as methylprednisolone to source immune system activity after a spinal injury – similar to how to epiPen is used to source an allergic reaction – but this method is scrapped due to its complicating side effects, such as sepsis, gastrointestinal bleeding and clots.

hand, employs non-pharmaceutical nanoparticles that redirect the immune cells from the spinal cord injury, while allowing the more helpful ones in to work the repairs.

Meanwhile, fewer immune cells will cause less inflammation and deterioration of nerve tissue.

"Hopefully, this technology Jonghyuck Park.

In the past, nanoparticles have been shown to reduce trauma caused by West Nile virus and multiple sclerosis.

"The immune system underlies autoimmune disease, cancer, trauma, regeneration – almost every major disease," says Shea. ["Toolsthatcantargetimmunecellsandreprogramthemtoadesiredresponsehavenumerousopportunitiesfortreatingormanagingdisease"


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