The interview comes when O'Rourke, who raised $ 80 million and formed a national democratic following during his close defeat to Sen. Ted Cruz last year, is making a presidential run.
The live event at the PlayStation Theater in New York City may be the first time that O Rourke – apart from its social media channels – has publicly asked questions since mid-December in a city hall in El Paso.
Interview conducted by Winfrey, aired on the Oprah Winfrey Network and published as a podcast.
Winfrey's network released details on the upcoming interview on Friday, and O & Rourke spokesman Chris Evans confirmed the performance.
O & R's political activity in recent weeks has focused primarily on preventing President Donald Trump's resistance to a wall along the US-Mexico border by posting videos on Facebook, Instagram and Twitter. Counselors and friends say he's considering a presidential run, but he's reluctant to spend more of his three small children after a grueling Senate campaign. O & Rourke is expected to make a presidential run in February at the earliest, according to two nearby sources.