Artificial sweeteners may still lead to obesity and diabetes, warns a new study
The consumption of low-calorie artificial sweeteners has increased dramatically in recent decades as people are aware of the health consequences of too much sugar.
However, new research shows that sugar replacement can also cause health changes associated with diabetes and obesity.
The research team led by Brian Hoffmann, assistant professor at the Department of Biomedical Engineering at the Medical College of Wisconsin and The Marquette University, fed various groups of rats that were high in sugar or conventional calorie-free sweeteners.
Subsequently, the team tracked biochemical changes in the body after eating sugar or sugar substitutes.
They also looked at effects on vascular health by examining how the substances affect the lining of blood vessels.
"In our studies, both sugars and artificial sweeteners appear to be negative, ie effects associated with obesity and diabetes, albeit through very different mechanisms," Hoffmann said.
The results suggest that artificial sweeteners change how the body processes fat and gains energy.
In addition, they found that acesulfame potassium, a common non-calorific sugar substitute, appeared to accumulate in the blood, with higher concentrations having a detrimental effect on blood vessel-carrying cells.
"We have observed that your body has modestly the machinery to handle sugar, and when the system is overloaded over a long period of time, this machine collapses," Hoffmann said.
"We have also observed that replacement of these sugars with calorie-free artificial sweeteners leads to negative changes in fat and energy metabolism. (1
" Much The research that points to negative effects of sweeteners is based on animal studies, especially mice and rats, should this not be done directly to humans because we have different metabolic pathways, "said Aisling Pigott, spokesman for the British Dietetic Association.