As a morning human (commonly called a lark), the risk of developing breast cancer is lower than that of late-night people (commonly referred to as owls). The recommended 7-8 hours per night may also increase the risk.
The authors have previously published a non-editorial, non-editorial version of this research paper on a recognized preprint server * and presented at the NCRI Cancer Conference in November 2018.
One in seven women will contract breast cancer at some point in their lives , Previous studies have shown an association between night shift work and breast cancer risk, presumably due to sleep disturbances, nocturnal light exposure, and other lifestyle factors. However, the potential impact of sleep habits on breast cancer risk has been much less studied.
An international research team therefore investigated whether certain sleep characteristics could have a direct (causal) influence on breast cancer risk.
Using a technique known as Mendelian Randomization, they analyzed genetic variants associated with three distinct sleep characteristics ̵
This analysis of genetic information avoids some of the problems that occur in traditional observational studies. This makes the results less susceptible to unmeasured (confusing) factors and therefore more likely to be more reliable.
An association observed by means of Mendelian randomization reinforces the inference to a causal relationship.
In the British Biobank observational analysis, the morning preference was associated with a slightly lower risk of breast cancer (one woman less per 100) than the evening preference, while there was little evidence of sleep duration and insomnia symptoms ,
However, the authors emphasize that this represents differences at the extreme end of the scale and that the magnitude of the effect is likely to be less than that of other known risk factors for breast cancer, such as breast cancer. BMI and alcohol consumption.
Mendelian analysis of British Biobank data provided some supportive evidence for a protective effect of morning preference on breast cancer risk, but inaccurate estimates for sleep duration and insomnia symptoms.
The Mendelian analysis of BCAC also supported a protective effect of morning preference and demonstrated a potentially deleterious effect of longer sleep duration (more than the recommended 7-8 hours) in breast cancer, whereas evidence of sleep disorders was inconsistent.
The researchers point to some limitations, for example, the study was based in part on self-reported sleep patterns and was restricted to women of European descent, so the results may not be applicable to other groups.
However, they used multiple methods to evaluate data from two groups of high-quality resources, taking into account established and potential risk factors. The results remained largely unchanged even after further sensitivity analyzes.
The researchers therefore state that their findings "provide strong evidence for a causal effect of the chronotype on breast cancer risk." Further work is needed to uncover possible causes for the associations between sleep disorder and breast cancer, they add. However, these findings have "potential impact on influencing the sleep habits of the general population to improve health."
In a linked editorial, Professor Eva Schernhammer of the University of Vienna says that "these findings indicate a need for future research Strain of our biological clock can be reduced. "
This provides a tremendous opportunity to maintain health, achieve healthy aging, and in particular to develop new personalized strategies to reduce the risk of chronic Circadian-related diseases." This research line could also help increase working hours to adjust the chronotype – to fine-tune externally imposed timing with individual preferences for daily work, especially in the workforce, "she concludes. EurekaAlert
As part of our efforts to further improve the content of our messages We conduct a reader survey to better serve you.
Please take two minutes to complete this questionnaire.
Thank you for your time. Click here to start
Download Daily Trust News App