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ASCO: Forget lung cancer history. Merck's Keytruda shatters the stats on long-term survival



CHICAGO-Before the dawn of immunotherapy, long-term survival was almost a foreign concept in the metastatic lung cancer. Keytruda Were Still.

At the American Society of Clinical Oncology Annual Meeting, the New Jersey drugmaker triggers outcomes that were 23.2% of previously untreated non-small cell lung cancer patients alive at the five-year mark.

That's beyond the figures of the field historically, according to Scot Ebbinghaus, MD, VP of clinical research at Merck Research Laboratories. Keytruda monotherapy, he said.

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"It was very uncommon to see five-year survival prior to the current era of treatment," he said, adding that "five-year survival." year survival for lung cancer has been steady, at least since I was in my oncology fellowship, at about 5%. "

RELATED: Merck's Keytruda wins coveted first-line lung cancer nod, cementing rise 'from laggard to leader '

Keytruda was the first in its class of PD-1

/ PD-L1 cancer-fighters to win at FDA nod in front-line NSCLC, and it's still the best only member to boast a solo approval in the indication. The various PD-L1 biomarkers

On the flip side, it was high-PD-L1 expressers who drove solo Keytruda's survival benefit in a closely watched phase 3 study that has been rolled out at last year's ASCO meeting. They found that the five-year figures were as high as: 29.6% of patients with tumor proportions scores of 50% or greater compared to the five-year benchmark, compared with just 15.7% of patients with PD-L1 levels below 50%. [19659003] RELATED: Merck's solo Keytruda wins again, but might just leave room for competition

25% of patients with PD-L1 levels of 50% or higher made the five-year target, compared with 12.6% of those with expression levels between 1% and 49%. 1% were alive after five years.


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