An affordable, globally available drug – low-dose aspirin – could help prevent HIV transmission, scientists say.
HIV infection rates remain unacceptably high, especially in young African women.
Researchers tested the effects of aspirin and other anti-inflammatory drugs on target HIV cells in a group of Kenyan women who were at low risk for HIV.
The study was published in the Journal of the International AIDS Society.
Transmission of The virus requires a sensitive target cell in the human host. Activated immune cells are more susceptible to HIV infection than quiescent cells. It is known that inflammation brings activated HIV target cells into the female genital tract.
They found that aspirin was most effective because it reduced the number of HIV target cells in the female genital tract by 35%
The number of HIV target cells in the women taking aspirin was approaching the level in Kenyan women at high risk of HIV contraction who were not infected for many years.