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Aspirin disappointed for the prevention of first heart attack, stroke



It has long been recognized that taking low-dose aspirin reduces the likelihood of a recurrent heart attack, stroke, or other heart problem in people who already had one, but the risks do not outweigh the benefits to most other people (19659002) Although aspirin has been used for more than a century, the value of aspirin is still unclear in many situations. The latest studies are some of the largest and longest to make these pennies a day blood thinners in people who do not have heart disease or a problem with blood vessels.

It was found that aspirin did not help to first prevent strokes or heart attacks in people at medium risk for one because they had several health threats like smoking, high blood pressure or high cholesterol.

Another aspirin tested in people with diabetes who are more likely to get heart disease or die, and found that the modest benefit was balanced by a greater risk of major bleeding.

Aspirin did not help to prevent cancer as hoped.

And fish oil supplements also tested in the study of people with diabetes

"There is a great deal of uncertainty among physicians around the world about the prescription of aspirin," beyond which it is now recommended for a study director, dr. Jane Armitage from Oxford University in England. "If you are healthy, it probably is not worth taking."

The research was discussed on Sunday at the meeting of the European Society of Cardiology in Munich. The aspirin trials used 1

00 milligrams per day, more than the 81 milligram pills commonly sold in the United States but still considered low-dose. Adult Strength is 325 milligrams

WHO IS REALLY HAZARDOUS?

A Boston-led study gave aspirin or dummy pills 12,546 people who were deemed to have a moderate risk of having a heart attack or stroke within a decade of other health problems

After five years, 4 percent had each Group a heart problem – much less than expected, suggesting that these people actually had a low risk, not moderate. Other medications they used to lower blood pressure and cholesterol levels could have reduced their heart risk so much that aspirin could do little more than help. J. Michael Gaziano from Brigham and Women's Hospital.

One percent of aspirin users had gastric or intestinal haemorrhages, usually mild – twice as many as in the case of oocytes. Aspirin users also had more nosebleeds, indigestion, reflux or abdominal pain

Bayer sponsored the study, and many researchers are consulting for the aspirin maker. Results were published by the journal Lancet.

ASPIRIN FOR PEOPLE WITH DIABETES?

People with diabetes are at greater risk for heart problems and strokes due to a blood clot, but also a higher risk of bleeding. The guidelines vary depending on which of them should consider aspirin.

Oxford researchers randomly identified 15,480 adults with Type 1 or 2 diabetes, but otherwise in good health with no history of heart problems, either aspirin, 1 gram of fish oil, both substances

After seven and a half years, there were fewer heart problems Aspirin patients, but more cases of serious bleeding, so they largely exchanged one risk for another.

FISH OIL RESULTS

The same study also tested omega-3 fatty acids, which found good oils in salmon, tuna and other fish. Supplementists did not fare better than those who gave dummy capsules – 9 percent of each group suffered a heart problem.

"We are very confident that it does not seem to matter for fish oil preparations for the prevention of heart disease," said study lead Dr. Louise Bowman of Oxford University

The British Heart Foundation was the main sponsor of the study. Bayer and Mylan provided aspirin and fish oil, respectively. The findings were published by the New England Journal of Medicine.

Other studies are testing different amounts and recipe versions of fish oil, "but I can not say people spend their money on it, we think it's probably better to eat fish," Dr. Holly Andersen, a specialist in the prevention of heart disease in New York-Presbyterian / Weill Cornell, who was not involved in the study.

The new research does not change guidelines on aspirin or fish oil, Dr. Nieca Goldberg, a cardiologist at the NYU Langone Medical Center and a spokeswoman for the American Heart Association. They recommend fish oil only for certain heart failure patients and say it is reasonable to consider for people who have already had a heart attack.

Marilynn Marchione can be followed at @MarchioneAP.

The Associated Press Health & Science Department receives support from the Department of Science Education of the Howard Hughes Medical Institute. All content is the sole responsibility of the AP.


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