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Aspirin disappointed for the prevention of first heart attack, stroke



It has long been recognized that taking low-dose aspirin every day reduces the likelihood of a recurrent heart attack, stroke, or other heart problem in people who have already had such risks Most other people, find great new research.

Although it has been used for more than a century, the value of aspirin is still unclear in many situations. The latest studies are some of the largest and longest to test these pennies a day blood thinners in people who do not have heart disease or a problem with blood vessels.

It was found that aspirin did not help to first prevent strokes or heart attacks in middle-risk people because they had several health threats like smoking, high blood pressure or high cholesterol.

Another tested aspirin in people with diabetes who are more likely to get heart disease or die, and found that the modest benefit was balanced by a greater risk of major bleeding.

Aspirin did not help to prevent cancer as hoped.

And fish oil supplements also tested in the study of people with diabetes

"There is a great deal of uncertainty among physicians around the world about prescribing aspirin" beyond which it is now recommended for a study director, dr. Jane Armitage from Oxford University in England. "If you are healthy, it probably is not worth taking."

The research was discussed on Sunday at the meeting of the European Society of Cardiology in Munich. The aspirin trials used 1

00 milligrams per day, more than the 81 milligram pills commonly sold in the United States but still considered low-dose. Adult strength is 325 milligrams.

WHO IS REALLY HAZARDOUS?

A Boston-led study gave aspirin or dummy pills to 12,546 people who were believed to have a moderate risk of having a heart attack or stroke in a decade suffering from other health problems.

After five years, 4 percent of each group had a heart problem – much less than expected, suggesting that these people actually had a low risk, not moderate. Other medications they used to lower blood pressure and cholesterol levels could have reduced their heart risk so much that aspirin could do little more than help. J. Michael Gaziano from Brigham and Women's Hospital.

One percent of aspirin users had gastric or intestinal haemorrhages, usually mild – twice as many as in the case of oocytes. Aspirin users also had more nosebleeds, indigestion, reflux or abdominal pain.

Bayer sponsored the study, and many researchers are consulting for the aspirin maker. The results were published by the journal Lancet.

ASPIRIN FOR PEOPLE WITH DIABETES?

People with diabetes are at higher risk for heart problems and strokes due to a blood clot, but also a higher risk of bleeding. Guidelines differ which of them should consider aspirin.

Oxford researchers randomized 15,480 adults with type 1 or 2 diabetes, but otherwise in good health and with no history of heart problems, either aspirin, 1 gram of fish oil, taking either substance, or dummy pills every day.

After seven and a half years, there were fewer heart problems among aspirin users, but more cases of serious bleeding, so they largely exchanged one risk for another.

FISH OIL RESULTS

The same study also tested omega-3 fatty acids, which found good oils in salmon, tuna and other fish. Supplement takers fared no better than those who gave dummy capsules – 9 percent of each group suffered a heart problem.

"We are very confident that it does not seem to matter for fish oil supplements for the prevention of heart disease," said study lead Dr. Louise Bowman of Oxford University

The British Heart Foundation was the main sponsor of the study. Bayer and Mylan provided aspirin and fish oil, respectively. The findings were published by the New England Journal of Medicine.

Other studies are testing different amounts and recipe versions of fish oil, "but I can not say people are spending their money on it, we think it's probably better to eat fish," Dr. Holly Andersen, a specialist in heart disease prevention in New York-Presbyterian / Weill Cornell, who was not involved in the study.

The new research does not change the aspirin guidelines or fish oil, Dr. Nieca Goldberg, a cardiologist at the NYU Langone Medical Center and an American Heart Association spokeswoman. They recommend fish oil only for certain heart failure patients and say it is sensible to think for people who have already had a heart attack.

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Marilynn Marchione can be followed at @MarchioneAP.

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Associated Press Health & Science Department receives support from the Department of Science Education of the Howard Hughes Medical Institute. The AP is solely responsible for all content.

Copyright 2018 The Associated Press. All rights reserved. This material may not be published, transmitted, rewritten or redistributed.


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