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Bacteria fight antibiotics



Researchers have discovered that the bacterium Pseudomonas aeruginosa – a pathogen that causes pneumonia, sepsis and other infections – communicates distress signals within a group of bacteria in response to certain antibiotics. It was found that this communication varies within the colony and suggests that this bacterium can develop protective behaviors that contribute to its ability to tolerate some antibiotics. The results indicate that the microbe may have some ability to protect the colony from some external toxins, even though it is still in a colonizing phase. The reported behavior was caused by tobramycin, an antibiotic commonly used in clinical situations, resulting in a dual signal response. Since this antibiotic was applied to a colony of P.aeruginosa the bacteria produced a signal to a localized area of ​​the colony ̵

1; a Pseudomonas quinolone (PQS) signal known to be as well as a second occurs, community-wide response, known as the alkylhydroxyquinoline (AQNO). The study was published in the Journal of Biological Chemistry .


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