She was 51.
Gillian Sheldon told CNN that Chapman had died earlier today and was surrounded by her family.
She was recently brought into a medically induced coma while fighting cancer.
Chapman and her husband were the stars of the hit reality show, which recorded the adventures of their family-owned bounty hunter and aired from 2004 to 2012.
He shared the news that she shared social media.
"It's 5: In Hawaii, this is the time she wakes up to hike Koko Head," he tweeted. "Just today she walked up the stairs to Heaven, we all love you, Beth, see you on the other side."
Beth Chapman was born in Denver, Colorado, and was the youngest woman ever to receive a bail for her home state, a record that was later broken by her daughter, Baby Lyssa.
Chapman dedicated himself to the bond business, where she worked for more than 30 years.
But it was the love affair between the Chapmans, as well as their adventures in the hunt for refugees, that thrilled the audience.
The couple raised 12 children together and shared their time between homes in Hawaii and Colorado.
The couple and their son Leland played in the three seasons from 2013 to 2015 in CMT's reality series Dog and Beth: On the Hunt.
In September 2017, the couple used the official Facebo ok account to confirm a report that they had been diagnosed with stage 2 throat cancer.
Later, during the A & E Special "Dog & Beth: Fight of Life", they revealed that the cancer had been eliminated and it was free of cancer
But the disease returned last year and Chapman began to overreach the followers to keep social media informed about their fight against cancer.
Her husband told Us Weekly in December that his wife was seeking alternative therapies and fighting for her health.  "Beth will not take anything the doctors want to give her, even the doctor told me he does not want her to have seizures when the pain is so bad, but she will not," he said. She will take over-the-counter pain medication and will not prescribe anything. "
"I'm a fighter, I'm a strong fighter – a great contemporary survivor – and I'll fight that as hard as I do," she said.
In April, her husband released a statement that she had been hospitalized and later released.
WGN America had been scheduled to debut a new series with the pair "Dogs Most Wanted" next year.
The network published a statement to CNN on Chapman's death.
"We are deeply saddened by the tragic news that Beth Chapman has lost her fight against cancer today," the statement said. "She was an extraordinary woman, deeply devoted and passionate about her life. It was a real pleasure Working with her family, we all at WGN America will miss her, our thoughts and prayers are with Duane, her family, relatives and millions of fans. "