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Body fat values ​​associated with breast cancer risk in postmenopausal women



"We find that excess body fat in people who have a normal body mass index after menopause is associated with a doubling in the risk of estrogen-dependent breast cancer," said Drs. Andrew Dannenberg, one of the authors authors of the study and director of cancer prevention at the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.
The American Cancer Society states that estrogen-dependent cancers, referred to in the study as ER-positive breast cancer, occur when the receptor proteins in or on the cells bind to and depend on the growth of estrogen, 3,460 American women between the ages of 50 and 79, who had gone through the menopause. The women were part of the Women's Health Initiative and their body composition was measured at the beginning of this program, Dannenberg said. Of these women, 1
46 developed ER-positive breast cancer, and the researchers looked for a link between excess body fat and the development of this cancer.

They found that a 5 kilogram increase in total body fat mass was associated with a 35% increased risk for this type of breast cancer. A 5 kilogram increase in the body's fat mass was accompanied by a 56% increase in risk.

Base fat, according to the study, is defined by "fat contained in the trunk except trunk and limbs."

The study also found that for invasive breast cancer that spreads to the surrounding breast tissue, a 5 kg increase in whole body fat mass is associated with a 28% increase in risk. The same increase in hull fat was associated with a 46% increase in the risk of invasive breast cancer.

"The main benefit is that excess body fat is associated with increased breast cancer risk even with normal body mass index," said Dannenberg.

A person's BMI is calculated using a formula that indicates their size and weight. A "normal" BMI is between 18.5 and 24.9 according to the study.

The researchers also examined the blood data that were recorded at the beginning of the Women's Health Initiative, on other factors known to play a role in this area. B. increase in insulin molecules.

The findings "highlight the importance of research that distinguishes the contributions of body height, body composition, and metabolic profiles to breast cancer risk," Drs. Isabel Pimentel, Ana Elisa Lohmann, and Pamela J. Goodwin wrote in an editorial published alongside the study.

The authors of the editorial also point out that other researchers have investigated the topic with varying results, and point out that "these observations indicate that components of metabolic health and not the presence of a complete metabolic syndrome contribute to breast cancer risk can".

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A particular strength of research for Hoda Anton-Culver, an excellent professor in the medical department of the University of California, Irvine , was the analysis of the position of body fat on the body.

"I think it's a good step forward, leading us from BMI as an indicator of obesity to a close look at fat levels in the body," said Anton-Culver, who was not involved in the research.

Scientists have known that there is an association between obesity and cancer, but Anton-Culver says the new study leads the research beyond this common link.

"They correctly say in the abstract that obesity is associated with breast cancer, but more specifically, obesity around the abdomen is more specific for this compound," she said.

Although Anton Culver considers the research strong, she pointed out that only one particular cancer was studied.

"I do not know if we are seeing the same problems with other cancers as a result, what will it be, is it specific to breast cancer?" She said. "We have to ask this question next, because obesity is a risk factor for other cancers."


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