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Can BP3 protein help with weight loss, metabolism?



Cancer researchers at Georgetown University came up with a surprising surprise when they examined the role of a specific protein in cancer.

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They found that the natural protein FGFBP3 (or BP3) proved to be a powerful regulator of metabolism, often giving a third of its fat to obese lab mice that were genetically predisposed.

The study, published in the journal Scientific Reports, suggests BP3 could be a new therapy in support of those suffering from metabolic syndromes such as type 2 diabetes and fatty liver disease.

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According to the Georgetown Medical Center, the BP3 protein is part of a family of binding proteins (fibroblast growth factor proteins) that are known to be involved in cell regulation, wound healing and injury response. These binding proteins are found in a variety of organisms, including humans.

"BP1

, 2, and 3 are" chaperone "proteins that attach to FGF proteins and enhance their activities in the body," researchers wrote in a university article. Senior investigator Anton Wellstein, who previously explored the BP1 gene for increased production of a variety of cancers, recently focused on BP3 to better understand the protein.

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During his research, Wellstein and his colleagues found that BP3 binds to three FGF proteins (FGF19, FGF21, and FGF 23), all of which are involved in metabolic control, making "BP3 a powerful motor of carbohydrate and carbohydrate." Makes lipid metabolism, "said Wellstein. "It's like we have a lot more taxis available in New York to pick up people who need a ride."

"The metabolism is accelerated, sugar in the blood and in the liver processed fat are used for energy and energy is not stored," he added. For example, FGF21's job is to control fat loss, whether stored or eaten. "

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Whether the BP3 protein can be used as a therapy for human metabolic syndromes is still a mystery and further investigation is needed, the authors said.

The latest 2015 figures from Atlanta 2016 show that 93.3 million adults in the United States are overweight. That's almost 40 percent of the population. Obesity in children and adolescents is also increasing.

Read the full Georgetown University study at nature.com .


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