24th June 2019 – Cannabidiol or CBD, which is already being researched and used against anxiety, insomnia, epilepsy and pain, may be the next Superbug fighter for resistant infections, according to a new study.
The researchers tested CBD against a variety of bacteria, including bacteria that have become resistant to the most widely used antibiotics, "says Mark Blaskovich, PhD, Senior Research Fellow, Center for Superbug Solutions, University of Queensland's Institute for Molecular Bioscience in Queensland, Australia.
Development is important as antibiotic resistance reaches a dangerously high level, according to the World Health Organization.
CBD is a non-psychoactive compound of cannabis and hemp Blaskovich presented Research Sunday at the annual meeting of the American Society for Microbiology, which includes work in test tubes and animal models. Research presented at sessions Results should be considered provisional until published in a peer-reviewed medical journal.
"First, we looked at CBD's ability to kill bacteria," he says. "In any case, CBD had a very similar efficacy to traditional antibiotics."
The researchers tested the CBD against some staphylococcal strains that cause skin infections, and streptococci that cause throat infections.
They compared the efficacy of CBD with common antibiotics such as vancomycin and daptomycin. "We looked at how fast the CBD kills the bacteria, it's pretty fast, within 3 hours, which is pretty good, Vancomycin (Vancocin) kills over 6 to 8 hours."
The CBD also destroyed the biofilm, the layer of bacteria that makes it difficult to invade and kill the antibiotic.
Finally, the laboratory studies showed that "CBD is much less likely to produce resistance than existing antibiotics," says Blaskovich.
"The CBD is selective for the type of bacteria," he says.
He found it effective against Gram-positive bacteria, but not against Gram-negative bacteria that cause serious skin infections and pneumonia among others Salmonella (inadequately cooked foods) and E. coli (the cause of urinary tract infections, diarrhea and other ailments).
Also featured in another study During the meeting, researchers tested current CBD for the treatment of skis n infection in mice After 48 hours, it has reduced the number of bacteria, Blaskovich says, even though it has not cleared the infection, this research is in progress.
How it could work, reservations
Researchers can not say exactly how that the CBD could prove to be a superbug infection fighter. "We thought it might work by w ir damage the outer membrane of the bacteria and make them leaky, "says Blaskovich. "It does not seem to do that, it could be a completely new mechanism of action."
He says the research results are promising, but at an early stage. He also warns people that it is far too early to self-treat infections with CBD.
The study was funded by Botanix Pharmaceuticals Ltd., which researches the use of CBD for skin conditions, and the Australian Government. Blaskovich is a consultant for Botanix.
Brandon Novy, a microbiology researcher at Reed College in Portland, OR, cites the results of the study as "very promising," as the results show that the bacteria could not form resistance to CBD and because the bacteria did not Biofilm could form.
Both findings are important. "Biofilm is an important part of the entire infection process," he says. "It helps the bacteria to bind themselves [to whatever surface or host] and survive."
At the same meeting, Novy presented a preliminary study that found that CBD is also promising to fight some Gram-negative infections.
"It's an important study that deserves to be followed up," says Dr. med. Amesh Adalja, infectious disease doctor and senior scientist at the Johns Hopkins Center for Health Security.
He was not involved in the new study. But he warns that it's important to keep everything connected. I think it's good that people are systematically investigating the use of CBD for infectious purposes. "
However, the work that has been done so far only applies to test tubes and animals, leaving many questions unanswered, such as whether it is toxic, dosed and the best way to administer the CBD, Adalja says, as well as warns against self-treatment CBD in Infections.