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Cells Shimmer Like a Thousand Ice Cream Sprinkles in Gorgeous New 'DNA Microscope' Images



 Cells Shimmer Like a Thousand Ice Cream Sprinkles in Gorgeous New 'DNA Microscope' Images

Each glowing dot represents a cell.

Credit: Joshua Weinstein, Broad Institute

What looks like a kaleidoscope of glowing ice The sprinkles or a cross between a nebula and a 1

980s dance party is actually something even more astonishing: an unfettered and detailed view of the exact locations of DNA and RNA inside a living cell.

look inside living cells – known as DNA microscopy – what a period of six years, according to a new study.

"DNA microscopy is an entirely new way of visualizing cells and captures both spatial and genetic information simultaneously" specimen, "study lead researcher Joshua Weinstein, a postdoctoral associate at the Broad Institute of MIT, said in a statement. [Check Out These Amazing Super-Detailed Images of Fruit Fly Brains]

The DNA is double helix and RNA's single strand, within each cell.

 The new technique is incredibly detailed. Compare this optical imaging image (left) of a cell population to the same cell population visualized with DNA microscopy (right). Scale bar = 100 micrometers.

The new technique is incredibly detailed. Compare this optical imaging image (left) of a cell population to the same cell population visualized with DNA microscopy (right). Scale bar = 100 micrometers.

Credit: Weinstein et al./Cell

"It makes allowance to see how genetically unique cells – those comprising the immune system, cancer or the gut, for instance – interact with one another and give rise to complex multicellular life, "Weinstein said.

Over the past few decades, researchers have developed myriad tools that help them collect molecular data from tissue samples.

The new approach makes the process easier, the researchers say. In essence, the method uses tiny tags – each of which is made up of DNA sequences each of which is about 30 nucleotides long-that latched onto each DNA and RNA molecule in a cell. Then, there are hundreds of copies of them within the cell.

The DNA between the two DNA tags is key. Once researchers collect the labeled Biomolecules and Sequence them, they can use a computer algorithm to decode and reconstruct the tags' original positions in the cell, creating a color-coded virtual image of the sample.

 Each dot in this sample, which looks like a smiley face, represents an individual cell. The colors indicate the type of DNA sequences within each cell.

Each dot in this sample, which looks like a smiley face, represents an individual cell. The colors indicate the type of DNA sequences within each cell.

Credit: Weinstein et al./Cell

The technique may help researchers better understand different types of human disease. For example, in the study the researchers showed that the DNA microscopy could map the locations of individual human cancer cells in a sample. These synthetic DNA tags may also be used in the locations of antibodies, receptors and molecules on tumor cells, they said.

"We've used DNA in a way that's mathematically similar to photons in light microscopy," Weinstein said.

The study was published online yesterday (June 20) in the Journal Cell.

Originally published on Live Science [This article is translated] 19659022].


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