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Certain prescription drugs linked to increased risk of dementia, study says



JAMA Internal Medicine Monday suggests that the link to anticholinergic drugs – particularly antidepressants, bladder antimuscarinics, antipsychotics and antiepileptic drugs.Researchers wrote in the study that "there is almost a 50% increase in odds of dementia" associated with a total anticholinergic exposure of more than 1.095 daily doses within a 10-year period, which is equivalent to an older adult taking "The anticholinergic drugs have long term associations with dementia risk," said Carol Coupland, a professor of medical science statistics in primary care at the University of Nottingham in the United Kingdom and first author of th e study. "It also highlights which types of anticholinergic drugs have the strongest associations. This is an informational statement on how to treat these anticholinergic drug causes. "She said that people taking these medications The study involved analyzing data on 284,343 adults in the United Kingdom, aged 55 and older, between 2004 and 201

6. The data came from QResearch, a large database of anonymized health records.The researchers identified each other as having anticholinergic drug antidepressant drugs overactive bladder.The researchers thus took a close look at who was diagnosed with dementia and found that 5 Antihistamines, skeletal muscle relaxants, gastrointestinal antispasmodics, antiarrhythmics or antimuscarinic bronchodilators, among other classes of anticholinergic drugs. The researchers found that the anticholinergic exposure was 1.49 among those with the highest exposure, compared with having no prescriptions for anticholinergic drugs their prescribed medication as directed, so anticholinergic exposure levels could have been misclassified. 10% of dementia diagnoses are attributable to anticholinergic drug exposure, which would equate 20,000 of the 209,600 new cases of dementia per year in the United Kingdom, "the researchers wrote in the study.Since the study shows only an association, more research is needed to" clarify whether anticholinergic medications truly represent a reversible risk factor "for dementia, wrote Noll Campbell, Richard Holden and Dr. Noll Malaz Boustani in JAMA Internal Medicine. "Additionally, de-prescribing trials can evaluate potential harms of stopping anticholinergic medications, such as worsening symptoms of depression, incontinence, or pain, as well as the potential unintended increase in acute health care utilization, "Campbell, Holden and Boustani wrote in the editorial." With little evidence of causation, the next steps for research on anticholinergic medications in older adults must improve the knowledge of the effects of prescribing interventions on cognitive outcomes and important safety outcomes such as symptom control, quality of life, and health care utilization, "they wrote. It has long been known that anticholinergic agents and confusion or memory issues are linked to it. Douglas Scharre, director of the Division of Cognitive Neurology at the Ohio State University, Wexner Medical Center, Columbus, who did not get involved in the study. "I spend a few days anticholinergic impact or is non-anticholinergic that may work, and many others may have anticholinergic properties, Scharre said, "Some of the medications that they are doing in the study may be quite critical and important and are well worth the taking of their seizures or their psychosis, and so it's a risk-benefit discussion," he adds. "So have a conversation with your doctor."

Scientists have found a possible link between anticholinergic drugs and an increased risk of dementia.

JAMA Internal Medicine Monday suggests that the link to anticholinergic drugs – particularly antidepressants, bladder antimuscarinics, antipsychotics, and antiepileptic drugs.

Researchers wrote in the study that "there is almost a 50% increase in odds of dementia" associated with a total anticholinergic exposure of more than 1.095 daily doses within a 10

"The anticholinergic drug has long-term anticholinergic effects." term associations with dementia risk, "said Carol Coupland, a professor of primary care statistics at the University of Nottingham in the United Kingdom and first author of the study.

"It also highlights which types of anticholinergic drugs have the strongest associations.

She said that people.

This is an informational statement on how to treat these drugs

The study involved analyzing data on 284,343 adults in the United Kingdom, aged 55 and older, between 2004 and 2016. The data came from QResearch, a large database of anonymized health records.

anticholinergic drugs antidepressants, drugs to treat vertigo, motion sickness or vomiting and bladder antimuscarinic drugs, seek as to treat overactive bladder.

The researchers thus took a close look at who was

The antihistamines, skeletal muscle relaxants, gastrointestinal antispasmodics, antiarrhythmics or antimuscarinic bronchodilators, according to the data, but associations were found among other classes of anticholinergic drugs.

among those with the highest anticholinergic exposure to 1.49 among those with the highest exposure, compared with having no prescriptions for anticholinergic drugs. [19659004TheanticholinergicexposurelevelscouldhavebeenmisclassifiedTheresearchersfoundonlyanassociationbetweenanticholinergicdrugsanddementiarisknotacausalrelationship

However, this association is causal, the population-attributable fractions indicate that around 10% of dementia diagnoses are attributable to anticholinergic drug exposure, 20,000 of the 209,600 new cases of dementia per year in the United Kingdom, "the researchers wrote in the study.

Since the study shows only an association, more research is needed to" clarify whether anticholinergic medications truly represent a reversible risk factor "for dementia, Noll Campbell, Richard Holden and Dr. Malaz Boustani in JAMA Internal Medicine.

"Additionally, de-prescribing trials can evaluate potential harms of stopping anticholinergic medications, such as worsening symptoms of depression, incontinence, or pain, as well as The potential unintended increase in acute health care utilization, "Campbell, Holden and Boustani wrote in the editorial.

" With little evidence of causation, the next steps for research on anticholinergic medications in older adults must improve the knowledge of the effect of " -prescribing interventions on cognitive outcomes and important safety outcomes such as symptom control, quality of life, and health care utilization, "they wrote.

It has long been known that anticholinergic agents and confusion or memory issues are linked to this association. Douglas Scharre, Director of the Division of Cognitive Neurology, Ohio State University, Wexner Medical Center, Columbus, United States.

19659004] "I have a lot of anticholinergic effects, and many have a long history of anticholinergic properties. anticholinergic that may work, "Scharre said."

"Some of the medications that they may have in the study may be quite critical and important and are well worth the taking of their seizures or their psychosis, and so it's a risk-benefit discussion, "he added. "So have a conversation with your doctor."

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