Alzheimer's disease is the leading cause of dementia – a syndrome (a group of related symptoms) associated with prolonged impairment of brain function.
It affects a person's cognitive function and affects their memory, thinking skills and other mental abilities.
Alzheimer's disease is a progressive disease, which means that the symptoms gradually develop over many years and eventually become more severe.
Most people associate Alzheimer's with memory loss, but an increased, excessive naps a day may also indicate the condition.  Earlier, the association between Alzheimer's disease and excessive napping was investigated. Now scientists in San Francisco have provided an explanation for this phenomenon.
According to a study published in Alzheimer's and Dementia, Alzheimer's disease directly attacks the responsible brain regions for vigilance during the day.
The new research shows that these brain regions are among the first casualties affected by narcolepsy neurodegeneration in Alzheimer's, which is why excessive naps during the day ̵
Evidence of this damage is associated with a protein known as tau demonstrated that tau contributes more directly to brain degeneration causing Alzheimer's symptoms than the extensively studied amyloid protein.
Tau protein naturally occurs in the brain and helps brain cells communicate with each other, Dementia UK explained.
"Our work shows definitive evidence that the pro-growth brain areas are due to accumulation of tau – not amyloid protein – from the very first town The disease is degenerating, "said study leader Lea T. Grinberg, MD, PhD, professor of neurology and pathology at the UCSF Memorial and Aging Center and a member of the Global Brain Health Institute and the UCSF Weill Institute for Neurosciences.
To conduct the investigation, senior author Jun Oh, a Grinberg lab researcher, and his colleagues have accurately measured Alzheimer's pathology, tau protein content and Alzheimer's syndrome neuron numbers in three brain regions, which help promote alertness of 13 deceased Alzheimer's patients and seven healthy control subjects and were drawn from the UCSF Neurodegenerative Disease Brain Bank.
Compared to healthy brains, Oh and colleagues found that the brains of Alzheimer's patients had been present in all three examined progenitor brain centers – the locus coeruleus (LC), the lateral hypothalamic area (LHA), and the tuberomammillary core (TMN ) – a significant tau buildup, and these regions had lost up to 75 percent of their brain centers neurons.
"It's notable because it's not just a single brain-nucleus that degenerates, but the entire awareness-raising network ork," Oh, said.
She added, "Crucially, the brain has no way to compensate because all of these functionally related cell types are destroyed at the same time."
Oh said, "It seems that the growth-promoting network is particularly vulnerable to Alzheimer's is, "said Oh. "To understand why this is the case, we need to look into future research.
" This suggests that in our ongoing search for Alzheimer's therapies, we must focus much more on the early stages of tau accumulation to understand in these brain regions. "
According to Alzheimer Research UK, determining a person's risk of Alzheimer's is complicated – it's a complex combination of age, genetics, and lifestyle.
However, the biggest risk factor for the development of late-onset Alzheimer's is age
According to NHS, Alzheimer's disease is most prevalent in people over the age of 65.
Alzheimer's Research UK also found that certain lifestyle-related factors associated with cardiovascular disease (such as heart disease and stroke) occur You may also increase a person's risk of developing Alzheimer's.
To stay healthy, the charity recommended:
- Be active and exercise regularly.
- Do not smoke.
- Eat healthy balanced diet
- Control high blood pressure
- Keep cholesterol at a healthy level
- Maintaining a healthy weight
- Drink alcohol only within the recommended limits.