People with diabetes are more likely to develop cancer because of the high blood sugar levels that affect DNA.
Higher blood sugar levels seem to increase the damage to DNA at the Hope National Medical Center, according to researchers from City of New York. Too much glucose in the blood also made DNA strands more susceptible to breakage and prevented their repair. In the opinion of the team, this could lead to so-called genomic instability: mutations that are characteristic of the majority of cancers.
The authors studied tissue in a laboratory and in mice with diabetes. This means that the results may not be applicable to humans but may give an indication of the processes in our body.
The study was presented at the National Meeting & Exposition of the American Chemical Society (ACS) in the fall of 201
Co-author John Termini, a professor at the Department of Molecular Medicine in City of Hope, stated, "As the incidence of diabetes continues to increase, the cancer rate is also likely to increase."
"In an ironic Fortunately, some cancer treatments increase the risk of diabetes, which in turn increases the risk of cancer. The destructive machine feeds on its own. "
Experts already know that both type 1 and type 2 diabetes are" significantly "associated with an increase in cancer, but the association is not well understood, the researchers wrote Authors in a Summary.
Understanding the relationship between cancer and diabetes is important to more than 100 million Americans with diabetes or pre-diabetes, the second largest killer in the US, leading to 599,108 deaths in 2017.
The team hopes that research can lead to the development of drugs that help with DNA repair, limit genomic instability, and reduce the risk of cancer in diabetics.
Medications such as metformin, which regulate blood sugar levels, could lower the risk of cancer. "Metformin helps lower blood sugar levels and stimulate DNA repair."
Published last fall A separate research team reported results suggesting that diabetes increases the risk of cancer, especially in women. The authors of the work Diabetologia examined existing evidence for 121 cohorts with over 19 million people.
Toshiaki Ohkuma, lead author of the study and research associate in the Kidney and Metabolism Department at George According to the Australian Institute for Global Health, women in the pre-diabetic stage of the disease, where glucose levels are high compared to men, often spend more time as men. Once the diagnosis is made, "women are often under-treated or do not receive the same treatment as men," said Ohkuma.