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Discovery could lead to drugs for traumatic brain injury



Scientists have identified two molecules that can protect nerve cells from traumatic brain injury and lead to new drug treatments.

The molecules promote complete recovery from craniocerebral trauma in mice, according to the new study in Neurobiology .

Traumatic brain injury is the leading cause of death in people under the age of 45 in the United States and is associated with disability, early-onset dementia, cognitive disorders, mental illness, and epilepsy [19659002] Almost all approaches to treating TBI focus The study notes that it is preventing neurons or nerve cells from degenerating or attempting to survive. TBI typically alters neural circuits in injured brain regions.

"The big problem with TBI treatment is that there are no medications that work well in patients to restore memory, and we're targeting the reconnectivity of neuronal circuits," says senior author Bonnie L. Firestein , Professor of Cell Biology and Neuroscience at Rutgers University, New Brunswick

"That means we want our neurons to function properly and connect to other neurons, and we want to enable people to increase their cognition and memory and learning skills Therefore, our point of view is new. "

Blood Test Detected Traumatic Brain Injury

Researchers tested the protein Cypin, an enzyme that degrades guanine, which is an important building block for DNA and RNA in cells. The scientists have previously shown that Cypin is involved in promoting the right shape in neurons and "makes them happy," says Firestein.

The new study found that accelerating the degradation of guanine protects neurons from injury and maintains brain function

Scientists at Rutgers-New Brunswick, the University of Pennsylvania, Columbia University, and Fox Chase Chemical Diversity Center Inc. want to develop drugs from the molecules for further study.

Source: Rutgers University


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