The development of resistant strains in Southeast Asia had "catastrophic consequences", researchers The drug dihydroartemisinin piperaquine (DHA-PPQ) has reached a failure rate of 62% in western countries Cambodia, 27% in northeast Cambodia, 53% in the southwest Vietnam and 87% in northeastern Thailand, researchers said in a statement.
The original strain of resistant malaria first spread to western Cambodia in 2008. Since then, it has evolved and mutated into several new subsets of resistant parasites, according to studies by several institutes, including the Wellcome Sanger Institute and the University of Oxford.
The speed with which subgroups have spread to neighboring countries suggests "improved fitness" and "increased survival benefit," researchers said, urging countries not to use DHA-PPQ.
An extremely successful resistant parasite strain can conquer new territories and gain new genetic traits. This raises the terrible prospect of spreading to Africa, where most malaria cases occur, as in the 1
Now that the DHA-PPQ drug fails, countries need to introduce alternative therapies and accelerate the elimination of resistant strains before they can
Malaria transmitted by the bite of female Anopheles mosquitoes is preventable and treatable – and is estimated at 435,000 people die every year.
Between 2000 and 2015 ga According to the World Health Organization (WHO), there is a 62% reduction in malaria deaths and a 41% reduction in the number of cases. Recent data, however, point to a comeback of malaria: According to a WHO report from 2018, malaria cases have increased significantly in 13 countries, and between 2016 and 2017 there is an increase of 2 million cases worldwide.
"It's a hard-to-treat disease The tools we have are modestly effective, but drugs and insecticides wear off and after 10, 20 years, mosquitoes become resistant," said Adrian Hill, director of the Jenner Institute at the Oxford University, opposite CNN earlier this year.  "There is a real concern that (cases) will rebound in the 2020s," he added.