قالب وردپرس درنا توس
Home / Health / Dutch study with Viagra stopped after 11 babies die

Dutch study with Viagra stopped after 11 babies die



AMSTERDAM (Reuters) – A Dutch study of sildenafil sold under the brand name Viagra was stopped immediately after 11 babies from mothers who took the drug had died, one of the participating hospitals said Tuesday.

When the study was discontinued on Monday, about half of the 183 participating pregnant women took sildenafil, said the University of Amsterdam's Academic Medical Center (AMC).

The study started in 2015 and included 11 hospitals. It was developed to investigate possible positive effects of increased placental blood flow in mothers whose unborn children were severely underdeveloped.

About 15 women taking the drug have not yet given birth.

"Previous studies have shown that sildenafil has a positive impact on baby growth, and the first results of the current study showed that it could have negative effects on the baby after birth," said the AMC.

However, the results showed that 1

7 babies with lung disease were born and 11 died. Under the roughly same control group, only three babies had lung problems and none died.

Among the women taking sildenafil, 11 of the babies died from "possibly related lung disease," which caused high blood pressure in the lungs, possibly due to decreased oxygen levels.

An interim analysis suggested that the likelihood of blood vessel disease in the lungs "appears to be greater and the likelihood of death after birth seems to have increased." The researchers found no positive effect on the children for other outcomes, "the AMC said ,

Stephen Evans, Professor of Pharmacoepidemiology at the London School of Hygiene and Tropical Medicine, said that the low number of studies with pregnant women has limited our knowledge of medicines in pregnant women.

"There have been other studies in this area that included both preliminary work with animals and pregnant women, and there was no evidence that the treatment was dangerous because of previous investigations," he said.

The drug was originally developed by Pfizer, but is now patent-free and available as a generic medicine. Pfizer did not have an immediate comment.

Reporting by Anthony Deutsch; Additional reporting by Kate Kelland and Ben Hirschler; Edited by Adrian Croft

Our Standards: The Thomson Reuters Trust Principles.

Source link