Guzmán achieved notoriety for twice escaping custody in Mexico as well as avoiding arrest on numerous other occasions.
Amongst others in his home state, he has the status of a folk hero, a popular subject of "narcocorridos" – musical tributes to drugs barons.
In 2016, he gave an interview to Hollywood actor Sean Penn in a Mexican jungle following his escape the previous year and boasted that he was the world's leading supplier of heroin, methamphetamine, cocaine and marijuana.
He was later recaptured in the north-western town of Los Mochis.  Image caption
New York's Brooklyn Bridge Guzmán drove across it
The US indictment against it is under pressure from six federal jurisdictions across the country, including New York, Chicago and Miami.
Prosecutors pooled together with more than a decade of evidence, including international partners seeking as Mexico
The trial jurors were anonymous and were excommunicated to and from the courthouse in Brooklyn by armed marshals after prosecutors argued that Guzman had a history of intimidating witnesses and even ordering their murders.