A Florida National Park has set a record 1
The female snake, the largest ever removed from the Big Cypress National Preserv, weighed 140 pounds (63.5 kg) and carried 73 eggs under development.
Pythons pose a major threat to indigenous wildlife in the state.
Researchers in the park track female breeding animals by equipping male pythons with radio transmitters.
"The team tracked one of the sentinel males with the transmitter and found this massive woman nearby," the park said on Facebook.
Big Cypress not only removes invasive snakes, but also uses every discovery to collect data for research and develop new removal tools, and learn how pythons use the area.
The Burmese Python has been considered an invasive species since it was first sighted in the Florida Everglades in the 1980s.
The species is native to Asia, but some pythons are thought to have been released into the wild as overgrown pets in Florida while others fled from a kennel destroyed by Hurricane Andrew in 1992.
The snakes have no natural predators in Florida, and the United States Geological Survey (USGS) says they have contributed to "drastic decreases" in mid-year mammals.
It is estimated that tens of thousands of Burmese pythons live in the Florida Everglades.