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Genes highlight five psychiatric disorders



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A group of international physicians has uncovered the genes that contribute to the development of ADHD, Autism Spectrum Disorder, Bipolar Disorder, Major Depression and Schizophrenia.

A joint research project by the University of Queensland and the Vrije Universiteit in Amsterdam analyzed more than 400,000 individuals to determine the genes behind these five psychiatric disorders disorders.

"Prior to this analysis, we knew that many psychiatric disorders are related because of their hereditary nature," said Professor Middeldorp.

"We often see several family members with mental illnesses in one family, but not necessarily the same disorder."

"We examined whether certain groups of genes were involved in the development of multiple disorders not only associated with ADHD, but also related to the other four psychiatric disorders. [1

9659004] "These are genes that play a role in the same biological pathway or are active in the same tissue type.

" Genes were expressed that are highly expressed in the brain to influence the various disorders, and some genes have been implicated all diseases investigated.

"It shows that there are a number of common genes that increase your risk for all five disorders."

The lead author of the study, Dr "We found that there are common biological mechanisms that work on disorders that all point to functions in brain cells," Dr. Hammerschlag. 19659004] "The synapse plays an important role as it is the junction between the brain cells where the cells communicate with each other."

"We also found that genes that are particularly active in the brain are important, while genes that are active in other tissues do not matter.

New drugs could potentially target these common routes.

"Our findings are an important first step in the development of new drugs that can be effective for a wide range of patients, regardless of their precise diagnosis" she said.

"This knowledge will bring us closer to developing more effective personalized medicine.

This study was published in Psychological Medicine .


Researchers identify 20 new gene associations with bipolar disorder


Further information:
Anke R. Hammerschlag et al. Synaptic and brain-expressed genetic clauses refer to the common genetic risk for five psychiatric disorders, Psychological Medicine (2019). DOI: 10.1017 / S0033291719001776

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University of Queensland




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Genes highlight five psychiatric disorders (2019, 24 July)
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