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Home / Health / Genetic researchers return wrinkles, gray hair and baldness in mice that are called "unprecedented"

Genetic researchers return wrinkles, gray hair and baldness in mice that are called "unprecedented"



Science has made mice look good by reversing age-related wrinkles and hair loss at the genetic level. Humanity could have a similar turnaround in the future.

"Wrinkled skin and hair loss are hallmarks of aging, what if they could be reversed?" Asked scientists from the University of Alabama in Birmingham, who, according to the research team, seem to have done this.

They introduced a specific gene mutation on a test mouse, resulting in a change in deep appearance. Within four weeks, the mouse had developed wrinkled skin and extensive, visible hair loss. When the normal function within the gene was restored by turning off the offender mutation, the mouse returned to an earlier life with smooth skin and luxurious fur just two months later ̵

1; which was considered "indistinguishable" from a healthy mouse of the same age.

To our knowledge, this observation is unprecedented, "said Keshav Singh, Professor of Genetics, who led the study.

" This mouse model should provide an unprecedented opportunity for the development of preventive and therapeutic drug development strategies to improve mitochondrial function Treatment of age-related skin and hair pathology and other human diseases in which mitochondrial dysfunction plays a significant role, "Mr. Singh said in a statement.

Throughout the study, the test mice received an antibiotic that caused them to change within the body All showed gray hair, thinning hair and hair loss, plus slowing movements and lethargy – changes that reminded the study of natural aging Women had stronger skin folds than men

"This hair loss and wrinkled skin could be dramatic Turning off the mutation can be reversed, "it says in the study. "The wrinkled skin showed similar changes as in intrinsic and extrinsic aging – intrinsic aging is the natural process of aging, and extrinsic aging is the effect of external factors that affect aging, such as skin folds that develop from excessive sunbeams (19659002) The research was supported by grants from the National Institutes of Health and the Department of Veterans Affairs and published in Cell Death and Disease, a scientific journal published by Nature.com [19659009] The Washington Times Commentary

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