Honolulu Fire Department Chief Manuel P. Neves said.
When firefighters arrived, the plane was engulfed in flames and they worked to extinguish them. Witnesses saw the plane coming inbound before it went down a fence, away from the runway, Neves said.
"This is the most tragic aircraft incident that we've had." Neves told CNN affiliate KGMB.
The names of the passengers have not been released.
The Federal Aviation Administration wants to take over the investigation.
This is an ongoing story. More updates to come.