The study suggests that an increase in organ donation through overdose deaths could help America's organ deficiency – but it also shows that between 2000 and 2017, many organs of overdose death donors were not used to save lives as they would have been
"The current epidemic of overdose deaths is a tragedy and it would be tragic to continue to use donor lifesaving grafts too little," said Drs. Christine Durand, assistant professor of medicine and oncology at Johns Hopkins University, who led the study.
"We have a duty to optimize transplant use of all donated organs." The donors, families, and patients waiting deserve our best effort to use every gift of life they can. "1
9659004 Durand added In addition, there are no regulations specific to the use of organs from the overdose of death that could limit these organs, but there are regulations regarding donors at "increased risk" for the transmission of certain viruses by organ transplantation.
"In our study, 56% of overdose death donors were identified as elevated donors of infectious risks, requiring special tests for HIV and hepatitis, and special consent for the transplant recipient." There is a stigma associated with this "increased risk of Infectious diseases, "said Durand.
"In reality, the" increased risk "of HIV or hepatitis in these donors is very low," she said.
"For people now waiting for an organ transplant I would like to believe that our studies bring them hope for a transplant and more donors who could help them" says Durand
"I also do not want to lose sight of the people who made these transplants possible: the donors and their families," she said. "In a time of greatest tragedy, they have made a powerful decision to save the lives of people waiting for a transplant, meaning they are generous, compassionate people, they are people I admire Organ donation and transplantation possible. "
The study included data from the Scientific Register of transplant recipients who included information on donors, waiting lists and transplant recipients between January 2000 and September 2017.  Researchers identified 7,313 overdose death donors in the data, during which at least one organ was restored. There were 19,897 transplants from these donors. The data showed that the number of overdose death donors increased by 17% per year between 2000 and 2017.
By comparison, the number of deaths increased by 1.6% per year and the death toll increased. The number of medical death donors increased by 2.3% per year.
A trauma death donor could be someone who has died from drowning, shooting or suffocation, among other things. A donor for medical deaths could have died from bleeding, stroke or heart attack, among other things.
In particular, the researchers found that the number of overdose death donors has increased from 66 in 2000 to 1.1% national pool, to 1263 in 2016, 12.7% and then to 915 in the first nine months 2017, including 13.4%.
The researchers also found that in 2016, overdose death donors accounted for at least 10% of donors in 29 states, with the highest percentages in Massachusetts at 35.6%, New Hampshire at 32.4%, New Jersey at 25.7%, New York at 23.1% and Maryland at 22.7%.
Overall, researchers found a 24-increase in the number of overdose death donor grafts from 149 in 2000 to 3,533 in 2016.
"Patients who received transplants from these donors had excellent results; Patients and organ function were similar to cases in which donors died from trauma and similar or better than cases in which the donor died due to medical causes of death such as heart attack or stroke, "said Durand. Despite the good results we found in transplant recipients, many were overdosed after overdose death rejected organs – that is, they were surgically obtained, but not used for transplantation in any patient, "she said
In the study, the researchers identified 1665 kidneys, 501 livers, 117 hearts and 23 lungs from overdose death donors who won but were discarded.
These organs were disposed of at a higher rate than those of trauma donors, but lower than those of the donors of medical death, the researchers found.For example, kidneys were overdose at a rate of 14.1% Death donors discarded, compared with 8.8% among trauma-death donors, but 26.1% among donors of medical deaths.
"This rejection was primarily with one increasingly "Prevalence of hepatitis C infection in overdose death donors and increased risk of infection," said Durand. "With a transplant, you always have to balance the risk and benefit," she said. "Patients and their transplant teams need to balance the low risk of infection, such as hepatitis C – for which we now have a cure, with the risk of dying on the waiting list."
"We have to save more lives"
The study had some limitations, including that researchers were unable to determine how many of the overdose death donors died specifically from opioid overdoses compared to non-opioid overdoses. States and jurisdictions also differ in their coverage of specific drugs involved in overdose deaths.
Dr. David Klassen, chief physician of the United Network for Organ Sharing, said in an e-mail that he considers the new study "interesting" and insights on the impact of opioid epidemic-related deaths on organ donation and outcomes for English: bio
"We at UNOS have observed that the number of organ donors has increased, especially in recent years, due to the tragedy of the The new study
said, "The study shows that the results of the recipients are similar to those of donors who die for other reasons." It also shows how the transplant system controls the use of organs from these donors has successfully integrated into clinical practice, which is beneficial to many patients, "Klassen said.
The undersupply of the organs with these donors still occurs and is probably underestimated Englisch: bio-pro.de/en/region/stern/magazin/…0/index.html "because it does not include organs that are never harvested, although benefits are offered to potential recipients," he said.
Dr. Camille Nelson Kotton, clinical director of the host's transplantation and immunocompromised infectious diseases at the Massachusetts General Hospital, wrote Editorial to the new study.
The editorial calls for increased efforts to provide organs to patients most likely to benefit from transplantation.
"We must save more lives from people waiting for an organ transplant," she wrote. "The transplant community should understand this new data and make progress on better transplantation outcomes for more recipients."