A team of Indo-American researchers at the University of Illinois in Urbana-Champaign (UIUC) and the University of Utah in Salt Lake City has used a brilliant technique to enable curcumin cancer kill cells. Curcumin is the active ingredient of turmeric (Haldi), the ubiquitous culinary spice that gives curry its yellow color. Turmeric has been used in India for thousands of years as a spice and medicinal herb because of its potent anti-inflammatory and strong antioxidant properties.
Curcumin is also known to show anti-cancer properties, but its poor solubility in water had worsened Curcumins clinical use in cancer. A drug must be soluble in water, otherwise it will not flow through the bloodstream. Despite decades of research, the development of efficient strategies that can deliver poorly water-soluble curcumin to cancer cells has remained challenging.
A team led by Dipanjan Pan, professor of bioengineering at UIUC, has now found a way out. "The medical benefits of curcumin can be fully recognized when its solubility problem is resolved," Pan told the correspondent in an e-mail.
Pan's lab worked with Peter Stang at the University of Utah to solubilize curcumin. transfer it to infected tumors and kill the cancer cells. Since platinum is a widely used cancer drug in the clinic, the researchers decided to experiment with a drug that consists of a combination of platinum and curcumin.
"It's a combination of sophisticated chemistry and nanoprecipitation using proprietary chemistry," Explained Pan. The sophisticated chemistry results in a self-assembled hierarchical structure that drives the solubility of curcumin while providing an additional anticancer agent, i. H. Platinum, supplies. The combined therapeutic effect ̵
The team has reported its work in the Proceedings of the National Academy of Sciences in the US The metallocyclic complex, which was made using platinum, not only enabled the solubility of curcumin, but also proved useful in the treatment of various cancers such as melanoma and breast cancer cells are 100 times more effective than the separate use of curcumin and platinum.
"Our results show that curcumin is fully synchronous with platinum and exhibits a synergistic effect to show remarkable anti-cancer properties," states "The platinum-curcumin combination kills the cells by fragmenting their DNA."
"Extensive animal studies are underway in my lab, including rodents and pigs," Pan said, and his team also hopes prove that this method can effectively kill cancer stem cells – the birthplace of cancer cells – and thus the recurrence of cancer cells Prevents cancer.
Follow @htlifeandstyle for more  First published: August 12, 2018 15:38 IST