"Wherever the US entered, it created instability and misery for people, so the US must be cut off from West Asia, and the US must leave this region," Ali Chamenei, Iran's top leader, said Monday in a tweet , Khamenei also accused the US of fueling tensions between Iran and Saudi Arabia.
The comments seem to be another signal that the US could withdraw from the Iran nuclear agreement within two weeks. US President Donald Trump must decide by May 12 whether to continue to waive sanctions against Iran, which has been lifted under the Iran Agreement, officially known as the Joint Comprehensive Plan of Action.
Under the 2015 Pact, which Trump predecessor Barack Obama, some European countries, Russia and China have agreed to, Iran needs to reduce its uranium supplies in return for lifting international sanctions.
"US officials are stirring up Saudis, creating discord and chaos in West Asia … they want to turn Muslims against each other," Khamenei said in a tweet. Iran and Saudi Arabia are long-standing regional rivals and have been involved in an escalating war of words in recent months.
In the series of tweets on Monday, the ayatollah said the US was planning to provoke "ignorant" governments, an apparent swipe in Saudi Arabia.
"If these government officials gain some wisdom, they will not confront the Islamic Republic, but if they oppose Iran, they will surely suffer from the defeat," Khamenei tweeted.
Iran says it will oppose any disarmament efforts. "The enemies want us to be disarmed while threatening us, which is an immoral, irrational and ambitious demand," said the Corvette captain of the Islamic Revolutionary Guard Corps on Monday, Fars Iranian News said.
Saudi Arabia accuses Iran of arming the Yemeni Houthi rebels. Saudi Arabia accused the group of using ballistic missiles from Iran during their attacks on the country in recent months.
Pompeo said on Sunday in Tel Aviv alongside Israeli Prime Minister Benjamin Netanyahu that they had spoken about Iran and repeated US support for Israel.
"In violation of the JCPOA"
Meanwhile, Britain, France and Germany – the three European countries that have participated in the deal – have tried to defend the deal against Trump's threats, themselves withdraw.
Macron said he wanted to maintain the original deal but called for further talks on areas that had been selected for criticism by the Trump administration. Trump has repeatedly argued against the so-called sunset provisions, which allow at certain times restrictions on the Iranian nuclear program.
Meanwhile Rohani accused Trump of breaking the deal.
The "current behavior of the United States would violate the JCPOA," Rohani said.
He added that the Trump government's negative comments on the deal "created fear and ambiguity for relations between different countries and companies and Iran," which undermined the benefits of the agreement.
CNN's Sheena McKenzie and Ben Wescott have contributed to this report.