Six people were killed and more than 1
The incident occurred near the eastern coastal town of Ancona.
There have been reports of panic after pepper spray was fired at the club in Corinaldo town.
Club Lanterna Azzurra hosted a concert by rapper Sfera Ebbasta and it was estimated that up to 1,000 people were inside at about 1:00 am (midnight GMT) when Italy celebrated the Feast of the Immaculate Conception.
The injured were taken to hospitals in Senigallia and Ancona. Many of the injured suffered serious injuries.
The local rescue services tweeted images from the scene:
Sfera Ebbasta is the stage name of the 26-year-old Gionata Boschetti, who has achieved considerable commercial success in Italy.  In January he released his third studio album – Rockstar – and was certified by the Italian Music Federation as a Triple Platinum seller.
In June last year, about 1,500 people were injured in Turin after a firecracker had triggered a storm soldier public showing of the Champions League final.