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Childhood brain tumor, discovered as "starving" cancer cells

A new method of treatment could soon be effective against a type of brain tumor that affects children and has previously been classified as incurable. It is the diffuse intrinsic pontingliom (dipg), a tumor that forms in a region of the brainstem called the varolio bridge that connects the brain to the spinal cord.

Children under 10 years and younger are usually affected Most patients do not survive more than one year after diagnosis. In a study published in Nature Communications, researchers from Yale University, Iowa University, and the Translational Genomics Research Institute (Tgen) found a way to disrupt the cellular process that contributes to the spread of the tumor. This pathology revolves around the mutation of the Ppm1

d gene, which is fundamental to the cell growth and stress response of the cells themselves.

Researchers identified a weak spot in the formation of a metabolite, Nad, necessary for cell life. They did this by examining Ppm1d, which, if changed, silences the Naprt gene, the key to the production of the metabolite Nad. If naprt is not available, switch to another protein needed to create nad. With an inhibitor drug, the researchers found that they can "starve" cancer cells.

« We found that the mutant Ppm1d gene essentially laid the foundation for his own death » said Michael Berens, one of the researchers who carried out the analysis. Last update: 21:27


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