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Home / Health / Laboratory-bred stem cells emit brain waves like newborns – and coffins form a robotic worm that slides through their heads. • The registry

Laboratory-bred stem cells emit brain waves like newborns – and coffins form a robotic worm that slides through their heads. • The registry



Madness in the brain

  Cortical organoid

An image of the lumpy cortical organoid cells. Photo credits: Muotri Lab / UCSD

Video Tiny brain cells grown in a petri dish can be made to emit electrical waves that resemble human-born waves, scientists have discovered for the first time.

A group of researchers discovered this curiosity when they decided to track the growth of individual pluripotent stem cells. These cell types can transform into any kind of cell or tissue in the body, be it the lungs, heart or brain.

The stem cells grow in a laboratory at the University of California in San Diego. (UCSD) were encouraged to become cerebral cortical cells, said Alysson Muotri, co-author of the study published in Cell, The Register .

"We start with single pluripotent stem cells and direct them towards a neuronal fate by exposing them to certain factors. Then the cells organize themselves and begin the maturation process, which in the course of time forms more connections.

Muotri, a professor at the Department of Pediatrics at UCSD, and his team observed how the brain cells developed into small clots called "cortical organoids" over ten months. As they increased in size, they discovered to their surprise that the cells emitted signals that resembled brainwaves.

"There is no precedent in science for this. I was very skeptical at first, but after we realized that this is not an artifact, we started believing it, "Muotri said.

It's the first time that these simple brainwaves have been detected in laboratory cells. but they have been discovered coming from fetuses. "Five years ago I would say that it is impossible to detect these waves in an artificially created brain organoid outside the uterus. Now I think it's inevitable, "he added.

When the cortical organoids matured, the scientists found that the emitted electrical spikes became more complex and fired at different peaks and frequencies. However, they are not nearly as electrically active as real, fully trained brains. Muotri said the organoids were more like the brain signals that produce newborns.

This could make it useful to study neurological or psychological conditions that are present in early brain development. "We are now creating brain organoids from people with autism and epilepsy to find better treatments with this model," he said.

A magnetic robot worm wriggling in your brain Brain is a fascinating organ, here's more new research. A group of engineers at the Massachusetts Institute of Technology has built a black, worm-like device that allows the blood vessels of the brain to move through intricate twists and turns.

Here you can wriggle.

youtube video

"Stroke is the fifth cause of death and the leading cause of disability in the US. If an acute stroke can be treated within the first 90 minutes, the survival rate of patients could increase significantly, "said Xuanhe Zhao, co-author of the article published in Science Robotics and Associate Professor of Mechanical Engineering and Civil and Environmental Engineering at MIT.

  brain

The neuroscientist used brainhack. It is very effective! Oh, and it's worryingly easy.

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"If we could develop a device that can reverse blood vessel obstruction within this" golden hour, "we might be able to avoid permanent brain damage. That's our hope. "

The thing is essentially a thin piece of wire coated with a hydrogel substance that can be magnetically controlled. In the experiments, the device was guided around an obstacle course consisting of several tubes filled with fluid. The researchers hope that one day they will be able to test their tools in real brains.

"Existing platforms could create a magnetic field and simultaneously fluoroscopy the patient, and the doctor could be in the other room or even in another city to control the magnetic field with a joystick," said Yoonho Kim, a PhD student at MIT. "In the next step, we hope to use the existing technologies to test our robotic filament in vivo." ®


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