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The study confirms the role of genetics in determining the age of menopause and familial longevity



If you're wondering why you've come into menopause sooner or later than other women, blame your mother. This is because numerous studies have confirmed the role of genetics in determining the age of a woman in menopause. A new study not only confirms this relationship, but also suggests a link with the longevity of the family. The findings are published online today in Menopause, the journal of the North American Menopause Society (NAMS) .

The age of menopause is defined clinically as one year after the last menstrual period, averaging about 52 years. However, every year, thousands of women surpass these statistics by entering menopause later, while many others naturally enter menopause much earlier.

However, menopause can occur earlier due to various illnesses such as smoking, chemo, and other conditions. Increased body mass index generally suggests that the age of menopause is most affected by family history. If your mother has experienced menopause early on, you can probably begin the transition in life sooner.

The aim of this latest study, which focused on reproductive life, was to identify genetic variants associated with the delayed age of menopause due to family reasons longevity. The results were based on a meta-analysis of several larger studies, including the Long Life Family Study, the Health and Retirement Study, and the Framingham Heart Study. These studies found that women who were able to reach children over the age of 40 were four times more likely to be average women living 1

00 years or older and that women who had children over the age of 35 years or older , with 1.5 times the probability of doing so after 100 years.

In this study, the researchers performed a meta-analysis for genetic variants associated with the age of menopause in women who eventually lived to very old age. The results provided further evidence for the genetic basis of menopausal age. In addition, the discovery of new variants suggests that there are genetic mechanisms of the menopausal age associated with the life expectancy of humans.

The results were published in the article "Genetic associations with the menopausal age in familial life expectancy".

Genetic variants associated with later menopause are associated with a longer lifespan. Although early menarche and total reproductive years have not been associated with slower aging, later menopause (longer reproductive potential) appears to be associated with slower aging.

Dr JoAnn Pinkerton, NAMS Managing Director

Source: ]

The North American Menopause Society (NAMS)

Reference: [HaroldH et al. (2019) Genetic associations with the age of menopause in family life expectancy. Menopause: The Journal of the North American Menopause Society . Doi .org / 10.1097 / GME.0000000000001367 [19659013<//
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