قالب وردپرس درنا توس
Home / Health / Male contraceptives stop sperm without affecting the hormones

Male contraceptives stop sperm without affecting the hormones



Credit: CC0 Public Domain

A recent study published in the journal PLOS ONE describes how a compound called EP055 binds to sperm proteins to significantly slow overall sperm motility without affecting hormones which makes EP055 a potential "male pill". without side effects.

"In short, the compound disables sperm's ability to swim, which significantly limits its ability to fertilize," said lead researcher Michael O'Rand, PhD, a professor of cell biology and physiology at the University of North Carolina Chapel Hill School of Medicine and President / CEO of Eppin Pharma, Inc. "This makes EP055 an ideal candidate for non-hormonal contraceptive methods."

Currently, condoms and surgical vasectomies are the only safe forms of birth control currently available to men. There are hormonal drugs in clinical trials aimed at the production of sperm, but these affect the natural hormones in men just as female contraceptives affect hormones in women.

During the study, 30 hours after a high-dose intravenous infusion of EP055 in male rhesus macaque, O & # 39; rand and researchers at the Oregon National Primate Research Center at OHSU in Portland, Oregon, found no evidence of normal sperm motility. In addition, no physical side effects were observed.

"Every 1

8 days after infusion, all macaques showed signs of complete recovery, suggesting that compound EP055 is indeed reversible," said researcher Mary Zelinski, research coordinator professor at the ONPRC at the OHSU and associate professor of obstetrics and Gynecology at the OHSU School of Medicine.

O & R and Zelinski point out that more work is needed before EP055 becomes available for human use. She and her teams have begun to test a pill form of the compound, and will eventually conduct a mating trial of the efficacy of EP055 against pregnancy.


Further information:
First hormone-free contraceptive pill will soon become reality

Sources in Journal:
Plus one

Provided by:
University of North Carolina Health Care


Source link