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Microbiome may be involved in mechanisms related to muscle strength in older adults



 Microbiome may be involved in mechanisms related to muscle strength in older adults
New study identifies differences in gut microbiome composition in terms of high-functioning vs. low-functioning older adults, Credit: Pixabay
            

A novel new study suggests that the microbiome has a role in older adults. The work, led by researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts, is available as a pre-proof in advance of print in Experimental Gerontology .
                                                

The good-muscle axis, or the relationship between good microbiota and muscle mass and physical function, has gained momentum as a research topic in the last few years as well. While researchers have begun exploring the connection between the good microbiome, muscle, and physical function in mice and younger adults,

To gain insight into this population of 1

8 older adults with a high-physical function and a favorable body composition with 11 older adults with low-physical function and a less favorable body composition.

Similar bacterial differences were present when mice were colonized with fecal samples from the two human groups, and the strength was increased in mice colonized with samples from the high-functioning Older adults, suggesting a role for the good microbiome in older adults.

Specifically, when compared to the low-functioning older adult group, the researchers found higher levels of Prevotellaceae, Prevotella, Barnesiella, and Barnesiella intestinihominis-all potentially good bacteria-in the high-functioning older adults and in the mice that were colonized with fecal samples from the high-functioning older adults.

No significant differences in body composition or endurance capacity were observed in the colonized mice ; however, the researchers said that they did not identify themselves with the role of microbiome on the maintenance of body composition Michael Lustgarten, last and corresponding author of the Nutrition and Exercise Physiology & Sarcopenia (NEPS) Laboratory at the HNRCA. Prevotella's role in the maintenance of muscle strength in older adults is one area

"As we age, body composition, muscle strength, and lean mass all decline," said first author Roger Fielding, director of the NEPS Laboratory at the HNRCA. "Identifying differences in bacteria present in the high-functioning and low-functioning groups in this study."

For the study, the researchers measured lower extremity function, mobility , and strength in the sedentary older adult group (ages 70-85) at the first and one-month study visits. In the mice, they are measured with quantitative magnetic resonance imaging, and grip strength and treadmill endurance capacity test physical function. Fecal samples from the older adults were transplanted into young, gender-matched germ-free mice. Four weeks after fecal transfer, the microbiome in the 18 mice colonized with fecal samples from the high-functioning human group and the 18 mice colonized with fecal samples from the low-functioning human group. 19659005] The authors note the small sample size and brief time period as potential study limitations.
                                                                                                                        


Study shows good microbiota skeletal muscle mass and function in mice


More information:
Roger A. Fielding et al, Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults, Experimental Gerontology (2019). DOI: 10.1016 / j.exc.2019.110722

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Tufts University




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                                                 Microbiome may be involved in mechanisms related to muscle strength in older adults (2019, September 18)
                                                 retrieved 18 September 2019
                                                 from https://medicalxpress.com/news/2019-09-microbiome-involved-mechanisms-muscle-strength.html
                                            

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