The investigators have discovered 35 bodies buried in the city of Guadalajara, the state prosecutors announced over the weekend.
The grisly discovery was another reminder of the undertaking facing Andres Manuel Lopez President Obrador, who took office in December. 29,000 murders in Mexico last year, according to Reuters.
Prosecutors revealed that they were buried at a ranch in Zapopan, a city in central Mexico next to Guadalajara.
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Among the dead, 27 had been tied up and two had been identified, the attorney general of Jalisco, Gerardo Octavio Solis, reportedly at a news conference.
Solis said the skull of seven other people and human remains were located on the property of a house located in Guadalajara, Mexico's second most densely populated city. Solis added that another body recovered from the Tlajomulco municipality, in Jalisco in central-western Mexico.
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Investigators did not reveal how long they believed the 35 recently discovered bodies had been buried.
Families with missing relatives reportedly rushed to officials in Jalisco asking for details on the bodies found. The state is home to one of Mexico's most powerful and dangerous drug gangs, the Jalisco New Generation Cartel.
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More than 40,000 people reportedly have vanished and have been presumed dead since Mexico's was on drugs was militarized with federal troops about 13 years ago.
Lopez Obrador said he was working to control the problem, but he said, "The first four months of his government surpassed those." recorded a year earlier.
The Associated Press contributed to this report.