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New & # 39; Trojan Horse & # 39; Antibiotic shows promise against UTI



Scientists say they have developed a new antibiotic that appears promising in early clinical trials for kidney infections and urinary tract infections (UTI).

The new antibiotic Cefiderocol acts like the "Trojan horse" in the Greek legend bacteria so they can enter, the BBC reported on Friday.

Studies on 448 individuals, reported in the Lancet Infectious Diseases Journal, with a kidney or UTI suggested that the drug was as effective as topical treatments.

"This important study offers hope for a new antibiotic that could possibly be an alternative to treat, but we are not there yet," said Serge Mostowy, a professor at the London School of Hygiene and Tropical Medicine.

The drug is inspired by the story of the giant wooden horse used to steal Greek warriors into the city of Troy.

But instead of wood, iron is used to smuggle an antibiotic into bacteria.

During an acute infection, one of our innate immune responses is to create a low-iron environment, "said Simon Portsmouth of Shionogi Inc., a Japanese pharmaceutical company that developed the drug.

" In response, bacteria increase their iron intake,

Cefiderocol binds to iron and, in a deadly mistake, bacteria transport it to their defenses and into their cells.

"Cefiderocol was found to be both safe and bearable," Portsmouth said 1

9659002] Bacteria that become resistant to antibiotics make some infections incredibly difficult to treat.

The report on antimicrobial resistance made strong predictions for the future, including 10 million people dying of drug-resistant infections by 2050. [19659002] New drugs are in short supply, the report said.

Experiments on Leu Those with pneumonia and those with infections that are resistant to some of our strongest drugs, carbapenems, are already in progress. However, much to ensure the efficacy of cefiderol, which attacks bacteria in a whole new way, larger studies are required, the researchers said.

– IANS

rt / mag / bg

(This story was not edited by Business Standard employees and is automatically generated from a syndicated feed.)


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