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New anti-inflammatory drug can treat sepsis



Researchers have developed an anti-inflammatory drug molecule that could lead to better treatment of diseases such as sepsis and possibly other autoimmune diseases.

"We have developed a new drug molecule that inhibits inflammation," said the lead author of the study Thomas Helleday from the Karolinska Institute in Sweden.

The discovery is the result of many years of research by the Helleday group on the way DNA is repaired by the body.

Researchers discovered that, to their surprise, it also dampened inflammation in the development of a new molecule that inhibits the enzyme that repairs the researchers with oxygen damage to the DNA.

It turned out that the enzyme OGG1

triggers inflammation in addition to the repair of DNA.

The inhibitor blocks the release of inflammatory proteins such as TNF alpha, said the study published in the journal Science.

In experiments on mice with acute lung disease, the researchers managed to reduce the inflammation.

Researchers found that the inhibitor works in a different way than other currently available anti-inflammatory drugs and could help prevent disease Our own immune system attacks itself in sepsis, multiple sclerosis, Crohn's disease, and possibly other autoimmune diseases.

Inflammation protects the body's white blood cells from infections such as bacteria and viruses.

However, under certain conditions, the immune system triggers an inflammatory response if there is no infection to defend. This causes the body's normally protective immune system to damage its own tissues.

"If oxygen regulation in our cells goes awry, it can damage our DNA and cause our immune system to react," said Helleday, who is also affiliated with the University of Sheffield in the UK.

"Our immune system is our defense mechanism that can normally prevent the invasion of bacteria and viruses, but sometimes misfiring and attacking our own body can occur."

"Isolating an inhibitor that can turn this response off It is a major breakthrough, and we are really looking forward to developing our research to see if we can not only alleviate existing inflammation in other areas of the body, but prevent inflammation altogether.

"This would pave the way for new, effective action treatments for life-threatening diseases such as sepsis," said Helleday.

– IANS

gb / sed

(This article was not edited by Business Standard employees and is automatically generated from a syndicated feed.)


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