Accurate and non-toxic treatment targeting nanoscale lung cancer cells can effectively kill cells even at low dose.
Washington State University researchers and the Department of Energy's Pacific Northwest National Laboratory (PNNL) used tiny tubes of organic molecules, called peptoids, to deliver targeted anti-cancer drugs.
The Yuehe Lin-led study Chun-Long Chen, a senior research scientist at the PNNL and joint faculty fellow at the University of Washington, was published as a cover story in the prestigious journal Small .
The biologically inspired nanotubes, which are about a hundred thousand times thinner than a human hair, were rolled up from membranous nanosheets. The drug molecules, fluorescent dyes and cancer targeting molecules have been precisely placed in the nanotubes to track the drug delivery efficiency into cancer cells.
With the new technology, the two drugs – one for chemotherapy and the other for treatment – can be used A less invasive photodynamic therapy delivered directly to cancer cells. Photodynamic therapy uses a chemical that releases reactive oxygen species (ROS) when exposed to light, killing cancer cells. The researchers' dual-drug approach enabled the use of a lower dose of anticancer drugs than the use of a single drug, resulting in the effective elimination of low-toxicity cancer cells.
Molecules allow scientists to uniquely locate tumor cells and track how the drug is being consumed, "Lin said." We can also track how nanotubes invade the cancer cell and deliver the drugs there. "
The team tested the nanotubes on lung cancer cells and found that they deliver the chemotherapy drug doxorubicin directly into the rapidly dividing cancer cells. Highly efficient killing of cancer with fewer chemotherapeutic agents.
"This is a promising approach for precision targeting with little damage to healthy surrounding cells," Lin said.  While other nanomaterials such as carbon nanotubes have been used Researchers have found that carcinogenic drugs are toxic to the body and were unable to accurately recognize molecules.
"These peptoids allowed us to synthesize highly programmable nanotubes and a bioko develop a responsive delivery mechanism, "said Chen. "We also used the high stability of the peptoid and its well-controlled packing to develop highly stable nanotubes."
"Because of their unique structure, these nanotubes can be easily assembled for cancer therapy and stay longer in the body for treatment," Lin said.
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Yanan Luo et al., Peptoid Nanotubes: Bioinspired Peptoid Nanotubes for the Targeting of Tumor Cells and Chemophotodynamic Therapy (Small 43/2019), Small (2019). DOI: 10.1002 / smll.201970231
New drug delivery technology promises efficient, targeted cancer treatment (2019, 22 October)
retrieved on October 22, 2019
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