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New study shows that the usual antidepressant in depression does not work as expected by experts



Since the first approval of the antidepressant sertralin (brand name Zoloft) in 1992, it has been an important support for doctors and psychiatrists prescribing medicines for depression. However, a new study suggests that Zoloft does not necessarily work against depression but still has a positive effect on many people.

Researchers at University College London Psychiatry in the UK carried out the so-called "biggest placebo ever" -controlled trial of an antidepressant drug that was not funded by the pharmaceutical industry. "The study, published by The Lancet Psychiatry on Thursday, recruited 653 people aged 18 to 74 years, who were not sure if prescribing drugs would help or not. Half of the patients received sertraline, the other a placebo, an inactive drug.

After six weeks, the study showed no evidence that sertraline reduced the symptoms of depression such as bad mood, loss of pleasure (anhedonia) and poor concentration. Sertraline had a minor effect only after 12 weeks. Most antidepressants are expected to work after four to six weeks. Although the researchers found only a small difference in depression, they noted a significant improvement in patients' anxiety symptoms at both six and twelve weeks.

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Notwithstanding the fact that the drug did not correlate directly with an improvement in depression, those in the study Sertralin still said their overall mental health had improved. Participants taking sertraline were twice as likely to report better overall mental health than those on placebo, suggesting that antidepressant use still had a measurable impact on mental health.

Most clinical studies indicate that antidepressants may not work exactly as doctors expect. However, the results may not be surprising given the overlap of depression and anxiety symptoms. Many people diagnosed with clinical depression have also been diagnosed with anxiety – the Anxiety and Depression Association (ADAA) estimates that nearly 50% of those affected suffer from depression.

The lead author of the study, dr. Gemma Lewis suggested the findings shed new light on older antidepressants as experts are not 100% sure how they work at all. In addition, Lewis said the findings suggest that reducing the mental health symptoms associated with depression or anxiety can help make people feel better.

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"It seems that people who are taking the drug themselves Feel less anxious, so they feel better overall, even if their depressive symptoms were less affected, "Lewis said in a news release." We hope we can shed new light on the way antidepressants work, as they may be in the first place Anxiety symptoms such as nervousness, anxiety and tension affect and it takes longer for depressive symptoms to occur. "

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