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No association between HPV vaccination and risk of autoimmune disease study



Electron micrograph of a negatively stained human papillomavirus (HPV) that occurs in human warts. Credit: public domain

A recent study in CMAJ ( Canadian Medical Association Journal ) found no increased risk of autoimmune disease in girls who received a quadrivalent human papillomavirus (HPV4) vaccine to the body evidence of the safety of the vaccine.

Human papillomavirus is the most commonly sexually transmitted disease in the world, affecting 50% to 75% of sexually active people. The HPV4 vaccine effectively protects against 90% of strains that cause cervical and anal cancer. Despite studies showing the safety of the vaccine, there were concerns about a possible link to autoimmune diseases.

"Despite proven efficacy in real-world environments, concerns over the safety of the HPV4 vaccine persist and we wanted to investigate the HPV4 vaccine because it is being offered in Ontario for free by all school-based clinics in Ontario," says Dr , Jeffrey Kwong, study author and senior scientist at the Institute for Clinical Evaluation Sciences (ICES) and Public Health Ontario

to determine whether the HPV4 vaccine causes autoimmune diseases such as lupus, rheumatoid arthritis, type 1

diabetes and multiple sclerosis The researchers data from 290 939 girls aged 12 to 17 years in Ontario for vaccination between 2007 and 2013. Of the total of 180 819 girls who received the HPV4 (Gardasil and Merck) vaccine in school clinics, 681 cases were diagnosed with autoimmune diseases between one week and two months after vaccination. This rate is consistent with the overall rate of diagnosed cases in this age group.

"These findings complement the evidence of the safety of the HPV4 vaccine and should reassure parents and healthcare providers," says Drs. Linda Lévesque, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario.


Further information:
Study confirms the safety of HPV4 vaccine for adolescents and young women in routine clinical care

Further information:
Erin Y. Liu et al. Quadrivalent Human Papillomavirus Vaccination in Girls and the Risk of Autoimmune Diseases: the Ontario Grade 8 HPV Vaccine Cohort Study, Canadian Medical Association Journal (2018). DOI: 10.1503 / cmaj.170871

Sources in Journal:
Journal of the Canadian Medical Association

Provided by:
Journal of the Canadian Medical Association


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