Researchers have discovered a potentially novel approach to bring therapeutics to the brain more effectively.
The results, which were made on mice, showed that the research could have implications for the treatment of a wide range of diseases, including Alzheimer's and Parkinson's, and brain tumor.
"Improving the delivery of drugs to the central nervous system poses a significant clinical challenge," said lead author Maiken Nedergaard of the University of Rochester Medical Center (URMC) in the US.
"The results of this study indicate that the brain waste management system could be used to deliver drugs to the brain quickly and efficiently," said Nedergaard.
The study uses the power of the glyph system, the brain's unique method of disposing of waste, first discovered by Nedergaard in 201
It consists of a sanitary system that piggybacks on the blood vessels of the brain and pumps it Cerebrospinal fluid (CSF) through the brain tissue, washing away waste.
In the study, published in the journal JCI Insight, the researchers used the mechanisms of the glyphatic system to bring drugs deep into the brain.
The team administers antibodies directly in CSF. They then injected the animals with hypertonic saline, a treatment commonly used to reduce intracranial pressure in patients with traumatic brain injury.
The saline triggers an ion imbalance that pulls CSF out of the brain. When this happens, new CSF supplied by the glyph system flows to bring the antibodies into brain tissue, the team said.
The researchers developed a new imaging system by adjusting a non-invasive macroscope to increase the number of antibodies in the brains of the animals.
They believe that not only large proteins, such as antibodies, but also small molecule drugs and viruses used in gene therapy, enter the brain with this method] – IANS
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