Pancreatic cancer is more lethal in patients overweight before the age of 50, new research suggests.
American Cancer Society scientists discovered that a BMI of 30 or higher increases the risk of pancreatic cancer killing a patient by 25 percent.
Current theories suggest that inflammation associated with obesity may stimulate cells to mutate and become cancerous.
Panreatic cancer has been on the rise in recent years. Alex Trebek struck, claiming that Ella Fitzgerald's startling physicians were the primary risk factor for smoking, but the new study suggests that obesity is guilty.
New research suggests that breast cancer is overweight in people who are overweight before age 50 – 25 percent more lethal – and in earlier humans The higher the pounds, the worse their chances [pancreatic cancer] is still considered Considered a rare form, but the rates have risen in recent years.
"This increase has confused us because smoking – a major risk factor for pancreatic cancer – is on the decline," says Dr. Eric Jacobs, scientific director of the American Cancer Society and co-author of the new study.
Although pancreas is one of the lesser-known forms of cancer, smoking is a known risk factor.
However, pancreatic cancer rates have continued to rise, although smoking has reached a record low in the US. The scientists are baffled and looking for another change that could drive the trend.
Now, scientists may have found a possible explanation: the obesity epidemic.
Obesity is a major risk factor for all types of diseases, including six cancers – the uterus, esophagus, stomach, kidney, liver, certain brain tumors, pancreatic and colon cancers, and multiple myeloma.
Research also suggests that obesity can make these cancers more lethal, and even if these people survive cancer, they are likely to have a poorer quality of life.
People who are overweight or obese, at some point in their lives, are 150 percent more likely to develop pancreatic cancer than people of normal weight.
Obesity is not considered a cause of cancer but a risk factor.
On the other hand, smoking was directly responsible for a quarter of cases of pancreatic cancer.
And since the number of Americans smoking has dropped 65 percent since 1965, pancreatic carcinoma has risen by 17.4 percent since 1999.
The new study suggests that the country's obesity trend may account for the mismatch.
"An increased weight in the US population is probably suspected, but previous studies have shown that overweight is associated with only a relatively small increase in risk. This does not seem to be big enough to fully explain the recent increases in pancreatic cancer rates, Dr. Jacobs.
But his new study changes that when one looks at being overweight, people gain when they are younger.
Dr. Jacobs and his team analyzed data from 963,317 people with no cancer history, starting in 1982, to see if those who were overweight before the age of 50 were more likely to develop pancreatic cancer.
8,354 of the group died of pancreatic cancer between 2014 and 2014.
And those who were overweight earlier in life were more likely to die, even if they were not fatally obese.
For example, a 5 7 7-inch person, who was 32 pounds overweight between the ages of 30 and 49, had a 25 percent higher risk of dying of pancreatic cancer than anyone who died at that age had healthy weight. [19659002Ifthispersonwasnearly50yearsoldthenabout50and59yearsoverweightof32kghadincreaseddeathcurrency19%andabout60%and69beyondweight14%
So, Earlier Life Someone gained the extra pounds as the weight gain increased the risk of dying from the elusive disease.
Based on these results, Dr. Jacobs that overweight will lead to 28 percent of pancreatic cancer deaths in people born between 1970 and 1974.
In contrast, he estimates that only 15 of the pancreatic deaths in individuals born in the 1930s were far less common than obesity.
Being overweight already increases the risk that a person will do so – developing cancer in general – and especially pancreatic cancer – by about 20 percent. The results of the new study underscore the crucial importance of healthy weight, especially at an earlier point in life.
"Our findings strongly suggest that we must stop and eventually reverse the increase in pancreatic cancer rates, so we need to be better at preventing weight gain in children and younger adults." Dr Jacobs said.