Are wrinkles just an inevitable consequence of aging, or could they signal something more sinister?
According to an annual conference of the European Society of Cardiology, presented today in Munich at the ESC Congress 2018 in Munich, which has much to offer with deep forehead wrinkles that are typical of their age, they may be at higher risk of developing cardiovascular diseases. Illnesses to die
The assessment of forehead wrinkles could be an easier and less costly way to identify people at high risk Category for CVD
"You can not see or feel any risk factors like high cholesterol or hypertension," says study author Yolande Esquirol, Associate Professor of Occupational Medicine at the Center Hospitalier Universitaire de Toulouse, France. "We explored forehead wrinkles as markers because they are so simple and visual, and if we only look at a person's face, it could trigger an alarm and then we can give advice to lower the risk."
This advice could also include direct lifestyle changes or eating healthier foods. "Of course, if you have a person with a potential cardiovascular risk, you'll need to review classic risk factors, such as blood pressure and lipid and blood sugar levels, but you might already share some recommendations on lifestyle factors," Dr. Esquirol
The risk of heart disease increases with age, but lifestyle and medical measures can reduce the risk. The challenge is to identify high-risk patients early enough to make a difference.
According to the authors of the study, previous research has analyzed various visible signs of aging to see if they can predict cardiovascular disease. In earlier studies crow's feet showed no relation to cardiovascular risk, but these tiny wrinkles near the eyes are a consequence of not only age but also facial movement. A link was found between hair loss in men, earlobes, xanthelasma (pockets of cholesterol under the skin) and a higher risk of heart disease, but not with an increased risk of actual dying. The study looked at another visible aging marker ̵
The study participants were observed for 20 years, during which time 233 died of various causes. Of these, 15.2% had two and three folds. 6.6% had a crease track and 2.1% had no kinking.
The authors found that individuals with a crease of one had a slightly higher risk of dying from cardiovascular disease than people without kinking. Those who had wrinkles of two and three had nearly 10 times the risk of dying compared to people who had wrinkle-zero, after adjustments for age, sex, education, smoking status, blood pressure, heart rate, diabetes and lipid levels,  "The higher the wrinkle score, the higher the cardiovascular mortality risk increases," explains Dr. med. Esquirol.
Fangs in the forehead are not a better way to assess cardiovascular risk than previous methods such as blood pressure and lipid profiles, but they could raise a red flag to a simple glance earlier.
The researchers do not yet know the reason for the relationship, which persisted even when factors such as job stress were taken into account, but theorize could do with atherosclerosis or arteriosclerosis due to plaque buildup. Atherosclerosis is a major factor in heart attacks and other cardiovascular events.
Changes in collagen protein and oxidative stress appear to play a role in atherosclerosis as well as in wrinkles. In addition, the blood vessels in the forehead are so small that they are more sensitive to plaque deposition, which means that wrinkles can be one of the early signs of vascular aging.
"Forehead wrinkles can be a sign of atherosclerosis," says Dr. Esquirol.
"This is the first time that an association has been established between cardiovascular risk and forehead wrinkles, so the results need to be confirmed in future trials," warns. Esquirol, "but the practice could now be applied in medical practices and clinics clinics."
"It costs nothing and there is no risk," Dr. Esquirol.
https://www.escardio.org/The-ESC/Press-Office/ Press Releases / Deep-forehead wrinkles-May-Signal-a-higher-risk-for-cardiovascular mortality