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Red wine resveratrol lowers blood pressure in mice: Could it do the same in human heart patients?



Resveratrol could one day be used to develop a new class of high-pressure medicines for humans, the researchers believe, who have explored the mechanisms of their mode of action. However, since they did not experiment with human patients, it has not been demonstrated that these "animal findings can be transmitted to humans," the authors of the study wrote from King's College London.

This is not your reason to drink plenty of red wine, they added.

Worldwide, about 40% of adults over the age of 25 have high blood pressure, while in the United States, 1 is considered 3 adults, according to the US Centers for Disease Control and Prevention. High blood pressure – when the force of blood pulsating on arterial walls is strong enough to cause health concerns ̵
1; is called a "silent killer" because it can lead to a heart attack or stroke without warning.
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The research team began its experiments with the induction of high blood pressure in mice. Then, some of the rodents were fed a high resveratrol diet for 15 days. The blood pressure of those who ingested much resveratrol decreased significantly when compared to normal-feeding mice.

How did that happen? Resveratrol relaxed the blood vessels, causing a drop in blood pressure because a protein called PKG1a had been oxidized in the vessel walls, the researchers said. They found that resveratrol works equally well in smooth muscle cells from human blood vessels.

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No Current Blood Pressure-lowering drugs target this physiological pathway, the researchers said, adding that resveratrol, previously referred to as an "antioxidant", is actually an oxidant: an atom that has one or more chemical reactions "Picking up" electrons from another party. Oxidizers cause cell damage, while antioxidants, which include natural and artificial substances such as vitamin C, can prevent or delay damage to cells because they provide electrons instead of stealing them.

The study also suggests that resveratrol lowers blood pressure skills could be accentuated in those who need it most: patients with heart disease. The beneficial compound must be activated to oxidize the protein, and these activating compounds are found in cardiac patients in higher concentrations, the researchers said.

Red wine is not the answer.

Bob Patton, a lecturer and alcohol researcher at the University of Surrey, pointed out that if you wanted to achieve the effective dosage found in the study, you would need to drink about 1,000 bottles of wine every day, "which of course is impossible."

A high dose was required because resveratrol must be broken down to reach its target in the blood vessel wall, and it does not dissolve well, the authors of the study said. Future drugs may require either altered, easily soluble resveratrol or synthetic compounds that mimic its beneficial effects.

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Patton, who was not involved in the study, told the Science Media Center that " Excessive alcohol consumption is associated with an increase in blood pressure, and this can lead to cardiovascular problems such as heart attack and stroke. "

It's a good idea to reduce and not increase wine consumption," he added Enjoying Glass of Red Wine [wine] is a way to relax at the end of the day, but that alone will not help combat high blood pressure, lose weight, exercise regularly and relieve stress, three of the best ways to do so are to

Roger Corder, Emeritus Professor of Experimental Therapeutics at Queen Mary University in London, told the Science Media Center that the mouse experiment of the Study had blood pressure effects that are "quite low. I am surprised that this paper has passed the umpire case traffic. "

It is more likely that a hypotensive effect is more due to the" use of very high concentrations of resveratrol than to a relevant biological effect, "said Corder, who was not involved in the study: "Based on the data presented It is difficult to draw satisfactory conclusions. "

" Most red wines have undetectable resveratrol levels, "he added," but the urban myth that resveratrol could explain the health benefits of regular red wine consumption has remained. "


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